Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial

被引：90

作者：

Hoscheidt, Siobhan ^{[1
]}

Sanderlin, Ashley H. ^{[1
]}

Baker, Laura D. ^{[1
]}

Jung, Youngkyoo ^{[2
]}

Lockhart, Samuel ^{[1
]}

Kellar, Derek ^{[1
]}

Whitlow, Christopher ^{[1
]}

Hanson, Angela J. ^{[3
]}

Friedman, Seth ^{[4
]}

Leverenz, James B. ^{[5
]}

Craft, Suzanne ^{[1
]}

机构：

[1] Wake Forest Sch Med, Winston Salem, NC 27101 USA

[2] Univ Calif Davis, Sacramento, CA 95817 USA

[3] Univ Washington, Med Ctr, Seattle, WA USA

[4] Seattle Childrens Hosp, Seattle, WA USA

[5] Cleveland Clin Lou Ruovo Ctr Brain Hlth, Cleveland, OH USA

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; cerebral perfusion; cerebrospinal fluid biomarkers; diet intervention; INSULIN-RESISTANCE; TAU PATHOLOGY; MOUSE MODEL; BRAIN; IMPAIRMENT; GENERATION; DEMENTIA; MEMORY; AGE;

D O I：

10.1002/alz.12421

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Mid-life dietary patterns are associated with Alzheimer's disease (AD) risk, although few controlled trials have been conducted. Methods Eighty-seven participants (age range: 45 to 65) with normal cognition (NC, n = 56) or mild cognitive impairment (MCI, n = 31) received isocaloric diets high or low in saturated fat, glycemic index, and sodium (Western-like/West-diet vs. Mediterranean-like/Med-diet) for 4 weeks. Diet effects on cerebrospinal fluid (CSF) biomarkers, cognition, and cerebral perfusion were assessed to determine whether responses differed by cognitive status. Results CSF amyloid beta (A beta)(42/40) ratios increased following the Med-diet, and decreased after West-diet for NC adults, whereas the MCI group showed the reverse pattern. For the MCI group, the West-diet reduced and the Med-diet increased total tau (t-tau), whereas CSF A beta(42)/t-tau ratios increased following the West-diet and decreased following the Med-diet. For NC participants, the Med-diet increased and the West-diet decreased cerebral perfusion. Discussion Diet response during middle age may highlight early pathophysiological processes that increase AD risk.

引用

页码：457 / 468

页数：12

共 52 条

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