Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults

被引：6

作者：

Topic, Aleksandra ^{[1
]}

Malic, Zivka ^{[2
]}

Francuski, Djordje ^{[3
]}

Stankovic, Marija ^{[3
]}

Markovic, Bojan ^{[4
]}

Soskic, Blagoje ^{[3
]}

Tomic, Branko ^{[3
]}

Ilic, Stefan ^{[3
]}

Dobrivojevic, Snezana ^{[5
]}

Drca, Sanja ^{[6
]}

Radojkovic, Dragica ^{[3
]}

机构：

[1] Univ Belgrade, Fac Pharm, Dept Med Biochem, Vojvode Stepe 450, Belgrade 11221, Serbia

[2] Univ Bijeljina, Fac Pharm, Bijeljina, Bosnia & Herceg

[3] Univ Belgrade, Inst Mol Genet & Genet Engn, Belgrade, Serbia

[4] Univ Belgrade, Fac Pharm, Dept Pharmaceut Chem, Belgrade, Serbia

[5] Ctr Hlth, Clin Chem Lab, Belgrade, Serbia

[6] Gen Hosp, Clin Chem Lab, Pancevo, Serbia

来源：

BIOMARKERS | 2016年 / 21卷 / 02期

关键词：

oxidative stress; microsomal epoxide hydrolase; glutathione-S-transferase; Cytochrome P450 1A1; MICROSOMAL EPOXIDE HYDROLASE; BODY-MASS INDEX; OBSTRUCTIVE PULMONARY-DISEASE; DNA-DAMAGE; LUNG-CANCER; URINARY 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; GENE POLYMORPHISMS; POPULATION; ASSOCIATION; REPAIR;

D O I：

10.3109/1354750X.2015.1126647

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Gender-related differences in the association between polymorphism of xenobiotic-metabolising enzymes or non-genetic biomarkers and susceptibility to oxidative stress was assessed in healthy middle-aged Serbian adults, by urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG/creatinine) and total antioxidant status in serum (TAOS). Females were more susceptible to oxidative stress. In both genders, positive predictor of the antioxidative protection was serum triglyceride, while BMI <25 kg/m(2) was associated with oxidative stress. Susceptibility to oxidative stress in males was associated with GSTT1*null allele and increased serum iron, but in females, it was decreased serum bilirubin. Early identification of the risk factors could be important in the prevention of oxidative stress-related diseases.

引用

页码：186 / 193

页数：8

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