Molecular Subtyping Based on Cuproptosis-Related Genes and Characterization of Tumor Microenvironment Infiltration in Kidney Renal Clear Cell Carcinoma

被引：34

作者：

Ji, Zhong-Hao ^{[1
,2
]}

Ren, Wen-Zhi ^{[1
]}

Wang, Hao-Qi ^{[1
]}

Gao, Wei ^{[1
]}

Yuan, Bao ^{[1
]}

机构：

[1] Jilin Univ, Coll Anim Sci, Dept Lab Anim, Changchun, Peoples R China

[2] Changzhi Med Coll, Dept Basic Med, Changzhi, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

kidney renal clear cell carcinoma (KIRC); cuproptosis; gene signature; overall survival; immune status; FDX1; IDENTIFICATION; POLYMORPHISMS; MECHANISMS; TNFSF13;

D O I：

10.3389/fonc.2022.919083

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of kidney renal clear cell carcinoma (KIRC) is rising worldwide, and the prognosis is poor. Cuproptosis is a new form of cell death that is dependent on and regulated by copper ions. The relationship between cuproptosis and KIRC remains unclear. In the current study, changes in cuproptosis-related genes (CRGs) in TCGA-KIRC transcriptional datasets were characterized, and the expression patterns of these genes were analyzed. We identified three main molecular subtypes and discovered that multilayer CRG changes were associated with patient clinicopathological traits, prognosis, elesclomol sensitivity, and tumor microenvironment (TME) cell infiltration characteristics. Then, a CRG score was created to predict overall survival (OS). The CRG score was found to be strongly linked to the TME. These findings may help elucidate the roles of CRGs in KIRC, potentially enhancing understanding of cuproptosis and supporting the development of more effective immunotherapy strategies.

引用

页数：13

共 49 条

[21] Comprehensive analyses of tumor immunity: implications for cancer immunotherapy [J].

Li, Bo ;

Severson, Eric ;

Pignon, Jean-Christophe ;

Zhao, Haoquan ;

Li, Taiwen ;

Novak, Jesse ;

Jiang, Peng ;

Shen, Hui ;

Aster, Jon C. ;

Rodig, Scott ;

Signoretti, Sabina ;

Liu, Jun S. ;

Liu, X. Shirley .

GENOME BIOLOGY, 2016, 17

[22] Generation and Analysis of Pyroptosis-Based and Immune-Based Signatures for Kidney Renal Clear Cell Carcinoma Patients, and Cell Experiment [J].

Lin, Gaoteng ;

Feng, Qingfu ;

Zhan, Fangfang ;

Yang, Fan ;

Niu, Yuanjie ;

Li, Gang .

FRONTIERS IN GENETICS, 2022, 13

[23] The Genotype-Tissue Expression (GTEx) project [J].

Lonsdale, John ;

Thomas, Jeffrey ;

Salvatore, Mike ;

Phillips, Rebecca ;

Lo, Edmund ;

Shad, Saboor ;

Hasz, Richard ;

Walters, Gary ;

Garcia, Fernando ;

Young, Nancy ;

Foster, Barbara ;

Moser, Mike ;

Karasik, Ellen ;

Gillard, Bryan ;

Ramsey, Kimberley ;

Sullivan, Susan ;

Bridge, Jason ;

Magazine, Harold ;

Syron, John ;

Fleming, Johnelle ;

Siminoff, Laura ;

Traino, Heather ;

Mosavel, Maghboeba ;

Barker, Laura ;

Jewell, Scott ;

Rohrer, Dan ;

Maxim, Dan ;

Filkins, Dana ;

Harbach, Philip ;

Cortadillo, Eddie ;

Berghuis, Bree ;

Turner, Lisa ;

Hudson, Eric ;

Feenstra, Kristin ;

Sobin, Leslie ;

Robb, James ;

Branton, Phillip ;

Korzeniewski, Greg ;

Shive, Charles ;

Tabor, David ;

Qi, Liqun ;

Groch, Kevin ;

Nampally, Sreenath ;

Buia, Steve ;

Zimmerman, Angela ;

Smith, Anna ;

Burges, Robin ;

Robinson, Karna ;

Valentino, Kim ;

Bradbury, Deborah .

NATURE GENETICS, 2013, 45 (06) :580-585

[24] Resistance to Systemic Therapies in Clear Cell Renal Cell Carcinoma: Mechanisms and Management Strategies [J].

Makhov, Peter ;

Joshi, Shreyas ;

Ghatalia, Pooja ;

Kutikov, Alexander ;

Uzzo, Robert G. ;

Kolenko, Vladimir M. .

MOLECULAR CANCER THERAPEUTICS, 2018, 17 (07) :1355-1364

[25] Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation [J].

Malta, Tathiane M. ;

Sokolov, Artem ;

Gentles, Andrew J. ;

Burzykowski, Tomasz ;

Poisson, Laila ;

Weinstein, John N. ;

Kaminska, Bozena ;

Huelsken, Joerg ;

Omberg, Larsson ;

Gevaert, Olivier ;

Colaprico, Antonio ;

Czerwinska, Patrycja ;

Mazurek, Sylwia ;

Mishra, Lopa ;

Heyn, Holger ;

Krasnitz, Alex ;

Godwin, Andrew K. ;

Lazar, Alexander J. ;

Stuart, Joshua M. ;

Hoadley, Katherine A. ;

Laird, Peter W. ;

Noushmehr, Houtan ;

Wiznerowicz, Maciej .

CELL, 2018, 173 (02) :338-+

[26] Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population [J].

Niu, Dan ;

Gao, Ya ;

Xie, Liyi ;

Sun, Jiping ;

Lu, Wanhong ;

Jin, Gang ;

Hao, Yaning ;

Zhang, Yali ;

Yin, Aiping ;

Geng, Yingzhou ;

Zhang, Wenjing ;

Chen, Cuiping ;

Li, Shengbin .

HUMAN IMMUNOLOGY, 2015, 76 (11) :831-835

[27] Association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy [J].

Niu, Dan ;

Ren, Yongchao ;

Xie, Liyi ;

Sun, Jiping ;

Lu, Wanhong ;

Hao, Yaning ;

Zhang, Yali ;

Yin, Aiping ;

Li, Huixian ;

Lv, Jia ;

Li, Shengbin .

NEPHROLOGY, 2015, 20 (12) :908-915

[28] The adjuvant treatment of kidney cancer: a multidisciplinary outlook [J].

Porta, Camillo ;

Cosmai, Laura ;

Leibovich, Bradley C. ;

Powles, Thomas ;

Gallieni, Maurizio ;

Bex, Axel .

NATURE REVIEWS NEPHROLOGY, 2019, 15 (07) :423-433

[29] Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data [J].

Racle, Julien ;

de Jonge, Kaat ;

Baumgaertner, Petra ;

Speiser, Daniel E. ;

Gfeller, David .

ELIFE, 2017, 6

[30] ENAM gene associated with T classification and inhibits proliferation in renal clear cell carcinoma [J].

Ren, Xiaohan ;

Liang, Shengjie ;

Li, Yang ;

Ji, Yisheng ;

Li, Lin ;

Qin, Chao ;

Fang, Kai .

AGING-US, 2021, 13 (05) :7035-7051

← 1 2 3 4 5 →