Synthesis, spectral and antimicrobial studies of chlorodiorganotin(IV)[3(2′-hydroxyphenyl)-5-( 4-substitutedphenyl) pyrazolinates]

Chlorodiorganotin(IV)pyrazolinates of the type R2SnCl(C15H12N2O center dot X) [where C15H12N2O center dot X =3(2 '-Hydroxyphenyl)-5(4-X-phenyl) pyrazoline {where X=H (a); CH3 (b); OCH3 (c); Cl (d) and R Me, Pr-n and Ph}] have been synthesized by reaction of R2SnCl2 with the sodium salt of pyrazolines in 1:1 molar ratio, in anhydrous benzene. These newly synthesized derivatives have been characterized by elemental analysis (C, H, N, Cl and Sn), molecular weight measurement and spectral studies [IR and multinuclear NMR (H-1, C-13 and Sn-119)]. The bidentate behavior of the ligands was confirmed by IR, H-1 and C-13 NMR spectral data. Trigonal bipyramidal structure around tin(IV) for R2SnCl(C15H12N2O center dot X) is suggested. The free pyrazoline and some chlorodiorganotin(IV) pyrazolinates have been screened for their antibacterial and antifungal activities. Some chlorodiorganotin(IV) pyrazolinates exhibit higher antibacterial and antifungal effect than free pyrazoline and some antibiotics.