Leucocyte/endothelium interactions and microvessel permeability: coupled or uncoupled?

被引:69
作者
He, Pingnian [1 ]
机构
[1] W Virginia Univ, Dept Physiol & Pharmacol, Sch Med, Morgantown, WV 26506 USA
基金
美国国家卫生研究院;
关键词
Microvessel permeability; Platelet adhesion; Platelet; leucocyte aggregation; Neutrophil ROS release; Leucocyte adhesion and migration; PLATELET-ACTIVATING-FACTOR; TUMOR-NECROSIS-FACTOR; ENDOTHELIAL CELL-INTERACTIONS; VESSEL WALL INTERACTIONS; VASCULAR-PERMEABILITY; ADHERENT LEUKOCYTES; SKELETAL-MUSCLE; FACTOR-ALPHA; MICROVASCULAR DYSFUNCTION; ACUTE-INFLAMMATION;
D O I
10.1093/cvr/cvq140
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In response to infections or tissue injury, circulating leucocytes adhere to and migrate from the vessel lumen to interstitial inflammatory sites to combat invading pathogens. However, these defensive actions may also cause host tissue injury and microvascular dysfunction through oxidative bursts or enzyme release. For decades, the interaction between leucocytes and microvessel walls has been considered as a critical event leading to organ dysfunction. Extensive investigations have therefore focused on blocking specific adhesive ligands to prevent tissue injury. However, anti-adhesion therapies have shown limited success in preventing vascular dysfunction in clinical trials. Numerous studies have demonstrated temporal and spatial dissociations of leucocyte adhesion and/or emigration from permeability increases. The mechanisms that initiate the adhesion cascade have been found to be distinct from those that trigger the leucocyte oxidative burst responsible for increasing microvessel permeability. Recent studies demonstrated that endothelial activation by inflammatory mediators is critical for initiating platelet adhesion and platelet-dependent leucocyte recruitment resulting in augmented increases in microvessel permeability. These new developments suggest that targeting endothelial activation via directly enhancing endothelial barrier function might be a more efficient strategy than focusing on anti-adhesion or platelet/leucocyte depletion to prevent vascular damage during inflammation. Owing to space limitations and the wide range of studies in the field, this article will not serve as a comprehensive review. Instead, it will highlight the emerging evidence of adhesion-uncoupled permeability changes and establish a basis for re-evaluating the coupled relationship between leucocyte/platelet activation and microvessel permeability to achieve a better understanding of permeability regulation during inflammation.
引用
收藏
页码:281 / 290
页数:10
相关论文
共 85 条
[1]   PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction [J].
Adamson, RH ;
Zeng, M ;
Adamson, GN ;
Lenz, JF ;
Curry, FE .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 285 (01) :H406-H417
[2]   NADPH oxidase: An update [J].
Babior, BM .
BLOOD, 1999, 93 (05) :1464-1476
[3]  
Baluk P, 1998, AM J PATHOL, V152, P1463
[4]   NK1 RECEPTORS MEDIATE LEUKOCYTE ADHESION IN NEUROGENIC INFLAMMATION IN THE RAT TRACHEA [J].
BALUK, P ;
BERTRAND, C ;
GEPPETTI, P ;
MCDONALD, DM ;
NADEL, JA .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1995, 268 (02) :L263-L269
[5]   Molecular cues guiding inflammatory responses [J].
Barreiro, Olga ;
Martin, Pilar ;
Gonzalez-Amaro, Roberto ;
Sanchez-Madrid, Francisco .
CARDIOVASCULAR RESEARCH, 2010, 86 (02) :174-182
[6]  
Becker Kyra J, 2002, Curr Med Res Opin, V18 Suppl 2, ps18, DOI 10.1185/030079902125000688
[7]   GENERATION OF SIGNALS ACTIVATING NEUTROPHIL FUNCTIONS BY LEUKOCYTE INTEGRINS - LFA-1 AND GP150/95, BUT NOT CR3, ARE ABLE TO STIMULATE THE RESPIRATORY BURST OF HUMAN NEUTROPHILS [J].
BERTON, G ;
LAUDANNA, C ;
SORIO, C ;
ROSSI, F .
JOURNAL OF CELL BIOLOGY, 1992, 116 (04) :1007-1017
[8]   Protective effects of leukopenia and tissue plasminogen activator in microvascular ischemia-reperfusion injury [J].
Bertuglia, S ;
Colantuoni, A .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 278 (03) :H755-H761
[9]   NEUTROPHIL-MEDIATED MICROVASCULAR DYSFUNCTION IN POSTISCHEMIC CANINE SKELETAL-MUSCLE - ROLE OF GRANULOCYTE-ADHERENCE [J].
CARDEN, DL ;
SMITH, JK ;
KORTHUIS, RJ .
CIRCULATION RESEARCH, 1990, 66 (05) :1436-1444
[10]   A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them [J].
Carman, CV ;
Springer, TA .
JOURNAL OF CELL BIOLOGY, 2004, 167 (02) :377-388