Effects of intrauterine growth retardation and Bacillus subtilis PB6 supplementation on growth performance, intestinal development and immune function of piglets during the suckling period

被引：69
作者：
Hu, Liang [1 ,2 ]
Peng, Xie [1 ,2 ]
Chen, Hong [3 ]
Yan, Chuan [1 ,2 ]
Liu, Yan [1 ,2 ]
Xu, Qin [1 ,2 ]
Fang, Zhengfeng [1 ,2 ]
Lin, Yan [1 ,2 ]
Xu, Shengyu [1 ,2 ]
Feng, Bin [1 ,2 ]
Li, Jian [1 ,2 ]
Wu, De [1 ,2 ]
Che, Lianqiang [1 ,2 ]
机构：
[1] Sichuan Agr Univ, Inst Anim Nutr, 46 Xinkang Rd, Yaan 625014, Sichuan, Peoples R China
[2] Minist Educ, Key Lab Anim Dis Resistance Nutr, 46 Xinkang Rd, Yaan 625014, Sichuan, Peoples R China
[3] Sichuan Agr Univ, Coll Food Sci, 46 Xinkang Rd, Yaan 625014, Sichuan, Peoples R China
来源：
EUROPEAN JOURNAL OF NUTRITION | 2017年 / 56卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Birth weight; Probiotics; Intestine; Barrier function; Immunity; NECROTIZING ENTEROCOLITIS; BIRTH-WEIGHT; DIETARY SUPPLEMENTATION; GASTROINTESTINAL-TRACT; PRETERM INFANTS; EARLY NUTRITION; RESTRICTION; PROBIOTICS; MORPHOLOGY; NEWBORN;
D O I：
10.1007/s00394-016-1223-z
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The aim of this study was to investigate the effects of intrauterine growth retardation (IUGR) and Bacillus subtilis PB6 supplementation in formula milk (FORM) on growth performance, intestinal development and immune function of neonates using a porcine model. Fourteen pairs of normal birth weight and IUGR piglets (7 days old) were randomly assigned to receive FORM or FORM supplemented with B. subtilis PB6 (FORM-BsPB6) for a period of 21 days. Blood samples, intestinal tissues and digesta were collected at necropsy and analysed for morphology, digestive enzyme activities, immune cell abundance, expression of genes associated with innate immunity and barrier function and microbial populations. Regardless of diet, IUGR significantly decreased average daily dry matter intake and average daily weight gain (P < 0.05). Moreover, IUGR significantly decreased plasma concentrations of immunoglobulin A, interleukin 1 beta, count and percentage of blood lymphocytes (P < 0.05). Meanwhile, IUGR markedly decreased villous height and maltase activity, as well as mRNA abundance of Toll-like receptor 9 and Toll-interacting protein in the ileum (P < 0.05). Regardless of body weight, FORM-BsPB6 markedly decreased the feed conversion ratio (P < 0.05), due to better intestinal development, as indicated by increased villous height (P < 0.05), activities of maltase and sucrase in the intestine (P < 0.10). Moreover, both mRNA and protein abundances of zonula occludens-1 and claudin-1 in the ileum as well as the copy number of Bacillus in colonic digesta were increased (P < 0.05) in piglets fed FORM-BsPB6 relative to FORM. The results of this study indicate that IUGR delayed growth, intestinal development and immune function of piglets, while FORM-BsPB6 improved digestive capability and intestinal barrier function.
引用
收藏
页码：1753 / 1765
页数：13
相关论文
共 50 条
[21]   Effects of dietary supplementation of bovine lactoferrin on growth performance, immune function and intestinal health in weaning piglets [J].
Xuanxuan Ma ;
Ya Hao ;
Ruoyu Mao ;
Na Yang ;
Xueling Zheng ;
Bing Li ;
Zhenlong Wang ;
Qingjuan Zhang ;
Da Teng ;
Jianhua Wang .
BioMetals, 2023, 36 :587-601
[22]   Effect of benzoic acid supplementation on growth performance and early development of gastrointestinal tract function and immune system in artificially reared suckling piglets [J].
Crone, C. M. ;
Rasmussen, A. P. ;
Larsen, C. ;
Williams, A. R. ;
Eskildsen, M. H. ;
Christensen, E. M. H. ;
de Knegt, L. V. ;
Amdi, C. ;
Madsen, J. G. .
LIVESTOCK SCIENCE, 2025, 294
[23]   Effects of Bacillus subtilis supplementation on growth performance, immunity, and intestinal health of juvenile Salmo trutta fario [J].
Lei, Kuankuan ;
Wang, Wanliang ;
Wang, Zhuangzhuang ;
Li, Ming ;
Zhou, Jianshe .
ANIMAL FEED SCIENCE AND TECHNOLOGY, 2025, 327
[24]   Intrauterine Growth Retardation Affects Intestinal Health of Suckling Piglets via Altering Intestinal Antioxidant Capacity, Glucose Uptake, Tight Junction, and Immune Responses [J].
Tang, Xiaopeng ;
Xiong, Kangning .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
[25]   Effects of alkaline mineral complex water supplementation on growth performance, inflammatory response, and intestinal barrier function in weaned piglets [J].
Chen, Jian ;
Xu, Ya-Ru ;
Kang, Jian-Xun ;
Zhao, Bi-Chen ;
Dai, Xue-Yan ;
Qiu, Bai-Hao ;
Li, Jin-Long .
JOURNAL OF ANIMAL SCIENCE, 2022, 100 (10)
[26]   Effects of Dietary Supplementation with Endogenous Probiotics Bacillus subtilis on Growth Performance, Immune Response and Intestinal Histomorphology of Juvenile Rainbow Trout (Oncorhynchus mykiss) [J].
Wang, Jing ;
Fan, Dan ;
Zhao, Ran ;
Lu, Tongyan ;
Li, Shaowu ;
Wang, Di .
FISHES, 2024, 9 (06)
[27]   Effects of Bacillus licheniformis on Growth Performance, Diarrhea Incidence, Antioxidant Capacity, Immune Function, and Fecal Microflora in Weaned Piglets [J].
Yu, Xiaorong ;
Cui, Zhenchuan ;
Qin, Songke ;
Zhang, Ruiqiang ;
Wu, Yanping ;
Liu, Jinsong ;
Yang, Caimei .
ANIMALS, 2022, 12 (13)
[28]   Effects of Dietary Supplementation with Combined Arginine and Glutamine on Growth Performance and Small Intestinal Development in Neonatal Piglets [J].
Xu, Qian ;
Jiang, Zongyong ;
Lin, Yincai ;
Zheng, Chuntian ;
Wang, Shikui .
JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2012, 11 (17) :3187-3193
[29]   Dietary nucleotides supplementation during the suckling period improves the antioxidative ability of neonates with intrauterine growth retardation when using a pig model [J].
Hu, Liang ;
Peng, Xie ;
Qin, Linlin ;
Wang, Ru ;
Fang, Zhengfeng ;
Lin, Yan ;
Xu, Shengyu ;
Feng, Bin ;
Wu, De ;
Che, Lianqiang .
RSC ADVANCES, 2018, 8 (29) :16152-16160
[30]   Effects of Bacillus megaterium on growth performance, serum biochemical parameters, antioxidant capacity, and immune function in suckling calves [J].
Yao, Jun ;
Wang, Lili ;
Zhang, Wenju ;
Liu, Mengjian ;
Niu, Junli .
OPEN LIFE SCIENCES, 2020, 15 (01) :1033-1041
12345