Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

被引:21
作者
Bai, Longchang [1 ,3 ,5 ]
Ma, Yingkang [1 ,3 ,5 ]
Wang, Xue [4 ]
Feng, Qiongni [1 ,3 ]
Zhang, Zhining [1 ,3 ,5 ]
Wang, Sijie [1 ,3 ,5 ]
Zhang, Huijie [1 ,3 ,5 ]
Lu, Xinyu [1 ,3 ,5 ]
Xu, Yonghui [1 ]
Zhao, Erhu [1 ,2 ,6 ]
Cui, Hongjuan [1 ,2 ,5 ,6 ]
机构
[1] Southwest Univ, State Key Lab Silkworm Genome Biol, Coll Sericulture Text & Biomass Sci, Chongqing, Peoples R China
[2] Southwest Univ, Canc Ctr, Med Res Inst, Chongqing, Peoples R China
[3] Southwest Univ, Westa Coll, Chongqing, Peoples R China
[4] Univ Chinese Acad Sci, Chongqing Gen Hosp, Chongqing, Peoples R China
[5] Chongqing Engn & Technol Res Ctr Silk Biomat & Re, Chongqing, Peoples R China
[6] Southwest Univ, Engn Res Ctr Canc Biomed & Translat Med, Chongqing, Peoples R China
来源
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
基金
中国国家自然科学基金;
关键词
polydatin; cervical cancer; c-Myc; cell viability; migration and invasion; TRANSCRIPTION FACTOR SNAIL; E-CADHERIN; PROLIFERATION; TRANSITIONS; CYCLE; GENE;
D O I
10.3389/fcell.2021.587218
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver. In this study, we demonstrated that polydatin has antitumor activity against human cervical cancer. Polydatin efficiently inhibited cervical cancer cell proliferation by regulating cell cycle-related proteins including p21, p27, CDK2, CDK4, Cyclin D1, and Cyclin E1. Furthermore, polydatin suppressed cell invasion and migration by regulating epithelial-mesenchymal transition (EMT) markers, including E-cadherin, N-cadherin, Snail and Slug. The c-Myc, as a proto-oncogene, is considered to be closely associated with the proliferation and metastasis of tumor cells. After polydatin treatment, the protein expression of c-Myc showed a significant decrease. Based on these data, we overexpressed c-Myc in cervical cancer cells and observed that the overexpression of c-Myc rescued the inhibitory effect of polydatin on cell proliferation and metastasis. These results indicated that polydatin can inhibit cell proliferation and metastasis through suppressing the c-Myc expression in human cervical cancer.
引用
收藏
页数:15
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