Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy

被引：1

作者：

Vatutin, N. T. ^{[1
]}

Taradin, G. G. ^{[1
]}

Maron, M. S. ^{[2
]}

Shevelek, A. N. ^{[1
]}

机构：

[1] Donetsk Natl Med Univ, Donetsk, Ukraine

[2] Tufts Univ, Sch Med, Hypertroph Cardiomyopathy Ctr, Tufts Med Ctr, Boston, MA 02111 USA

来源：

KARDIOLOGIYA | 2016年 / 56卷 / 01期

关键词：

hypertrophic cardiomyopathy; sudden cardiac death; epidemiology; arrhythmogenic substrate; risk stratification; implantable cardioverter-defibrillator; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; OUTFLOW TRACT OBSTRUCTION; BLOOD-PRESSURE RESPONSE; VENTRICULAR-ARRHYTHMIAS; RISK STRATIFICATION; ATRIAL-FIBRILLATION; UNEXPECTED DEATH; AMERICAN-COLLEGE; PROGNOSTIC VALUE; TROPONIN-T;

D O I：

10.18565/cardio.2016.1.56-65

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This literature review is devoted to the problem of studying sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). It covers prevalence of SCD and its structure among young individuals and trained athletes, contains discussion of relation of SCD to sex, age, and hypertrophic response of myocardium to physical exercise. Modern views on arrhythmogenic substrate underlying SCD in HCM as well as pathophysiologic cascade of life-threatening ventricular tachyarrhythmia are presented in detail. Approaches to identification of individuals at high risk of SCD are described and main and supplemental clinical criteria are discussed from the point of view of SCD risk stratification. The review also contains results of large trials assessing the role of implantable cardioverter-defibrillators (ICD) in primary and secondary prevention of SCD in HCM patients, and recommendations on appropriateness of ICD implantation taking into account efficiency of these devices and rate of complications.

引用

收藏

页码：56 / 65

页数：10

相关论文

共 84 条

[1] Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy on relation to delayed enhancement on cardiovascular magnetic resonance [J].

Adabag, A. Selcuk ;

Maron, Barry J. ;

Appelbaum, Evan ;

Harrigan, Caltlin J. ;

Buros, Jacqueline L. ;

Gibson, C. Michael ;

Lesser, John R. ;

Hanna, Constance A. ;

Udelson, James E. ;

Manning, Warren J. ;

Maron, Martin S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (14) :1369-1374

[2] Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy [J].

Adabag, AS ;

Casey, SA ;

Kuskowski, MA ;

Zenovich, AG ;

Maron, BJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (05) :697-704

[3] The prognostic importance of left ventricular outflow obstruction in hypertrophic cardiomyopathy varies in relation to the severity of symptoms [J].

Autore, C ;

Bernabò, P ;

Barillà, CS ;

Bruzzi, P ;

Spirito, P .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (07) :1076-1080

[4] Impairment of Ubiquitin-Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction [J].

Bahrudin, Udin ;

Morikawa, Kumi ;

Takeuchi, Ayako ;

Kurata, Yasutaka ;

Miake, Junichiro ;

Mizuta, Einosuke ;

Adachi, Kaori ;

Higaki, Katsumi ;

Yamamoto, Yasutaka ;

Shirayoshi, Yasuaki ;

Yoshida, Akio ;

Kato, Masahiko ;

Yamamoto, Kazuhiro ;

Nanba, Eiji ;

Morisaki, Hiroko ;

Morisaki, Takayuki ;

Matsuoka, Satoshi ;

Ninomiya, Haruaki ;

Hisatome, Ichiro .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 413 (04) :857-878

[5] Severe Cardiac Conduction Disturbances and Pacemaker Implantation in Patients With Hypertrophic Cardiomyopathy [J].

Barriales-Villa, Roberto ;

Centurion-Inda, Raul ;

Fernandez-Fernandez, Xusto ;

Ortiz, Martin F. ;

Perez-Alvarez, Luisa ;

Rodriguez Garcia, Isabel ;

Hermida-Prieto, Manuel ;

Monserrat, Lorenzo .

REVISTA ESPANOLA DE CARDIOLOGIA, 2010, 63 (08) :985-988

[6] Postmortem diagnosis in sudden cardiac death victims: macroscopic, microscopic and molecular findings [J].

Basso, C ;

Calabrese, F ;

Corrado, D ;

Thiene, G .

CARDIOVASCULAR RESEARCH, 2001, 50 (02) :290-300

[7] Myocardial bridging, a frequent component of the hypertrophic cardiomyopathy phenotype, lacks systematic association with sudden cardiac death [J].

Basso, Cristina ;

Thiene, Gaetano ;

Mackey-Bojack, Shannon ;

Frigo, Anna Chiara ;

Corrado, Domenico ;

Maron, Barry J. .

EUROPEAN HEART JOURNAL, 2009, 30 (13) :1627-1634

[8] Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice [J].

Baudenbacher, Franz ;

Schober, Tilmann ;

Pinto, Jose Renato ;

Sidorov, Veniamin Y. ;

Hilliard, Fredrick ;

Solaro, R. John ;

Potter, James D. ;

Knollmann, Bjoern C. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (12) :3893-3903

[9] Response to cardiac resynchronization therapy predicts survival in heart failure: A single-center experience [J].

Cha, Yong-Mei ;

Rea, Robert F. ;

Wang, Ming ;

Shen, Win-Kuang ;

Asirvatham, Samuel J. ;

Friedman, Paul A. ;

Munger, Thomas M. ;

Espinosa, Raul E. ;

Hodge, David O. ;

Hayes, David L. ;

Redfield, Margaret M. .

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2007, 18 (10) :1015-1019

[10] PROGNOSTIC UTILITY OF CONTRAST-ENHANCED CARDIOVASCULAR MAGNETIC RESONANCE IN HYPERTROPHIC CARDIOMYOPATHY: AN INTERNATIONAL MULTICENTER STUDY [J].

Chan, Raymond H. ;

Maron, Barry ;

Olivotto, Iacopo ;

Assenza, Gabriele ;

Hong, M. Susie ;

Lesser, John ;

Haas, Tammy ;

Gruner, Christiane ;

Crean, Andrew ;

Rakowski, Harry ;

Udelson, James ;

Rowin, Ethan ;

Tomberli, Benedetta ;

Spirito, Paolo ;

Formisano, Francesco ;

Biagini, Elena ;

Rapezzi, Claudio ;

De Cecco, Carlo Nicola ;

Autore, Camillo ;

Cook, Earl Francis ;

Hauser, Thomas ;

Gibson, C. Michael ;

Manning, Warren ;

Appelbaum, Evan ;

Maron, Martin .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (13) :E1570-E1570

← 1 2 3 4 5 6 7 8 9 →