Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice

被引:124
作者
Bereczky, Sandor [1 ]
Lindegren, Gunnel [1 ]
Karlberg, Helen [1 ]
Akerstrom, Sara [1 ]
Klingstrom, Jonas [1 ,2 ]
Mirazimi, Ali [1 ,2 ]
机构
[1] KCB Swedish Inst Infect Dis Control, SE-17182 Solna, Sweden
[2] MTC Karolinska Inst, SE-17177 Stockholm, Sweden
关键词
RIFT-VALLEY FEVER; CLINICAL-FEATURES; RESPONSES; PATHOGENESIS; LIVESTOCK; OUTBREAK; ANTIBODY; AFRICAN;
D O I
10.1099/vir.0.019034-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Crimean-Congo hemorrhagic fever virus (CCHFV) poses a great threat to public health due to its high mortality, transmission and geographical distribution To date, there is no vaccine or specific treatment available and the knowledge regarding its pathogenesis is highly limited. Using a small-animal model system, this study showed that adult mice missing the type 1 interferon (IFN) receptor (IFNAR(-/-)) were susceptible to CCHFV and developed an acute disease with fatal outcome In contrast, infection of wild-type mice (129 Sv/Ew) was asymptomatic. Viral RNA was found in all analysed organs of the infected mice, but the amount of CCHFV RNA was significantly higher in the IFNAR(-/-) mice than in the wild-type mice Furthermore, the liver of IFNAR-/- mice was enlarged significantly, showing that IFN is important for limiting virus spread and protecting against liver damage in mice.
引用
收藏
页码:1473 / 1477
页数:5
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