Although regions of the sensorimotor cortex, insula, and anterior cingulate gyrus are reported to be activated during swallowing, findings concerning contributions of the cerebellum and basal ganglia have been contradictory. We investigated cerebellar and basal ganglionic activation using functional magnetic resonance imaging (fMRI). In 11 subjects, single-shot gradient-echo echoplanar image volumes sensitive to BOLD contrast were acquired in block design fashion using an oblique orientation covering both cerebrum and cerebellum. Using statistical parametric mapping, regional activation upon swallowing was observed in the sensorimotor cortex, insula, cerebellum, putamen, globus pallidus, thalamus, anterior cingulate gyrus, supplementary motor area, superior temporal gyrus, and substancia nigra. The cerebellum was activated bilaterally, especially on the left; activation of the putamen and globus pallidus was also found bilaterally. Thus, volitional swallowing involves the cerebellum and basal ganglia as well as cortical structures. The method used was well tolerated by normal subjects and should also be applicable to patients with dysphagia.
机构:
Sichuan Univ, W China Hosp, Dept Rehabil Med, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
Li, Shasha
Luo, Cheng
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Univ Elect Sci & Technol China, Sch Sci & Technol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
Luo, Cheng
He, Chengqi
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Sichuan Univ, W China Hosp, Dept Rehabil Med, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
He, Chengqi
Gong, Qiyong
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Sichuan Univ, W China Hosp, Dept Radiol, HMRRC, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
Gong, Qiyong
Zhou, Dong
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Sichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R ChinaSichuan Univ, W China Hosp, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China
机构:
Univ Sao Paulo HCFM USP, Fac Med, Inst Cent Hosp Clin, Speech Therapy Orofacial Funct,Speech Therapy Sup, Sao Paulo, SP, BrazilUniv Sao Paulo HCFM USP, Fac Med, Inst Cent Hosp Clin, Speech Therapy Orofacial Funct,Speech Therapy Sup, Sao Paulo, SP, Brazil
de Lima, Maira Santilli
Mangilli, Laura Davison
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Univ Sao Paulo, Fac Med, Sci, BR-09500900 Sao Paulo, SP, Brazil
Univ Sao Paulo HCFM USP, Fac Med, Hosp Clin, Rehabil Sci Med Invest Lab, Sao Paulo, SP, BrazilUniv Sao Paulo HCFM USP, Fac Med, Inst Cent Hosp Clin, Speech Therapy Orofacial Funct,Speech Therapy Sup, Sao Paulo, SP, Brazil
Mangilli, Laura Davison
Sassi, Fernanda Chiarion
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Univ Sao Paulo, Fac Med, Sci, BR-09500900 Sao Paulo, SP, Brazil
Univ Sao Paulo FM USP, Fac Med, Dept Phys Therapy Speech Therapy & Occupat Therap, Sao Paulo, SP, BrazilUniv Sao Paulo HCFM USP, Fac Med, Inst Cent Hosp Clin, Speech Therapy Orofacial Funct,Speech Therapy Sup, Sao Paulo, SP, Brazil
Sassi, Fernanda Chiarion
Furquim de Andrade, Claudia Regina
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Univ Sao Paulo FM USP, Fac Med, Sao Paulo, SP, BrazilUniv Sao Paulo HCFM USP, Fac Med, Inst Cent Hosp Clin, Speech Therapy Orofacial Funct,Speech Therapy Sup, Sao Paulo, SP, Brazil
机构:
Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Huang, Haiyue
Yan, Jin
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Yan, Jin
Lin, Yinghong
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Fujian Univ Tradit Chinese Med, Coll Integrated Chinese & Western Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Lin, Yinghong
Lin, Jiaxin
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Lin, Jiaxin
Hu, Huimin
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Hu, Huimin
Wei, Linxuan
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Wei, Linxuan
Zhang, Xiwen
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Zhang, Xiwen
Zhang, Qingqing
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Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China
Zhang, Qingqing
Liang, Shengxiang
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机构:
Fujian Univ Tradit Chinese Med, Natl Local Joint Engn Res Ctr Rehabil Med Technol, Fuzhou, Peoples R China
Fujian Univ Tradit Chinese Med, Rehabil Ind Inst, Fuzhou, Peoples R China
Fujian Univ Tradit Chinese Med, Tradit Chinese Med Rehabil Res Ctr State Adm Tradi, Fuzhou, Peoples R ChinaFujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Peoples R China