Age-related effects of TGF-β on proteoglycan synthesis in equine articular cartilage

被引：40
|
作者：
Iqbal, J [1 ]
Dudhia, J [1 ]
Bird, JLE [1 ]
Bayliss, MT [1 ]
机构：
[1] Univ London Royal Vet Coll, Dept Vet Basic Sci & Farm Anim & Equine Med & Sur, London NW1 0TU, England
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 274卷 / 02期
关键词：
cartilage; TGF-beta; proteoglycan; mRNA;
D O I：
10.1006/bbrc.2000.3167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of proteoglycans was measured in normal equine articular cartilage of ages 9 months to 20 years and the effect of TGF-beta 1 on this activity was investigated. The rate of incorporation of [S-35]Na2SO4 decreased with age as did the responsiveness of the tissue to the growth factor. The enhanced synthesis of proteoglycan induced at all ages by TGF-beta 1 was down-regulated by IL-1 beta and retinoic acid. The expression of mRNA for TGF-beta 1, 2, and 3 was also measured, and although the level of TGF-beta 1 was highest at all ages, the expression of each growth factor decreased with age. (C) 2000 Academic Press.
引用
收藏
页码：467 / 471
页数：5
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