Age-related effects of TGF-β on proteoglycan synthesis in equine articular cartilage

被引：40
|
作者：
Iqbal, J [1 ]
Dudhia, J [1 ]
Bird, JLE [1 ]
Bayliss, MT [1 ]
机构：
[1] Univ London Royal Vet Coll, Dept Vet Basic Sci & Farm Anim & Equine Med & Sur, London NW1 0TU, England
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 274卷 / 02期
关键词：
cartilage; TGF-beta; proteoglycan; mRNA;
D O I：
10.1006/bbrc.2000.3167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of proteoglycans was measured in normal equine articular cartilage of ages 9 months to 20 years and the effect of TGF-beta 1 on this activity was investigated. The rate of incorporation of [S-35]Na2SO4 decreased with age as did the responsiveness of the tissue to the growth factor. The enhanced synthesis of proteoglycan induced at all ages by TGF-beta 1 was down-regulated by IL-1 beta and retinoic acid. The expression of mRNA for TGF-beta 1, 2, and 3 was also measured, and although the level of TGF-beta 1 was highest at all ages, the expression of each growth factor decreased with age. (C) 2000 Academic Press.
引用
收藏
页码：467 / 471
页数：5
相关论文
共 50 条
  • [21] Expression of TGFβ-family signalling components in ageing cartilage: age-related loss of TGFβ and BMP receptors
    van Caam, A.
    Madej, W.
    Thijssen, E.
    de Vinuesa, A. Garcia
    van den Berg, W.
    Goumans, M. -J.
    ten Dijke, P.
    Davidson, E. Blaney
    van der Kraan, P. M.
    OSTEOARTHRITIS AND CARTILAGE, 2016, 24 (07) : 1235 - 1245
  • [22] Differential effects of local application of BMP-2 or TGF-β1 on both articular cartilage composition and osteophyte formation
    van Beuningen, HM
    Glansbeek, HL
    van der Kraan, PM
    van den Berg, WB
    OSTEOARTHRITIS AND CARTILAGE, 1998, 6 (05) : 306 - 317
  • [23] Halofuginone attenuates articular cartilage degeneration by inhibition of elevated TGF-β1 signaling in articular cartilage in a rodent osteoarthritis model
    Mu, Wenbo
    Xu, Boyong
    Ma, Hairong
    Ji, Baochao
    Zhang, Zhendong
    Li, Jiao
    Amat, Abdusami
    Cao, Li
    MOLECULAR MEDICINE REPORTS, 2017, 16 (05) : 7679 - 7684
  • [24] Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis
    van der Kraan, Peter M.
    BIO-MEDICAL MATERIALS AND ENGINEERING, 2014, 24 : S75 - S80
  • [25] Relationship between age-related serum concentrations of TGF-β1 and TGF-β2 and those of osteoprotegerin and leptin in native Chinese women
    Zhang, Na
    Wu, Xi-Yu
    Wu, Xian-Ping
    Fu, Xiao-Hua
    Du, Xiao-Yong
    Xie, Hui
    Peng, Yi-Qun
    Luo, Xiang-Hang
    Liao, Er-Yuan
    CLINICA CHIMICA ACTA, 2009, 403 (1-2) : 63 - 69
  • [26] The Age-Related Changes in Cartilage and Osteoarthritis
    Li, YongPing
    Wei, XiaoChun
    Zhou, JingMing
    Wei, Lei
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [27] Relationships between age-related biochemical markers of bone turnover and OPG, TGF-β1 and TGF-β2 in native Chinese women
    Chen, Chao
    Liang, Meng-Ke
    Zhang, Hong
    Peng, Yi-Qun
    Wu, Xian-Ping
    Wu, Xi-Yu
    Liao, Er-Yuan
    ENDOCRINE RESEARCH, 2014, 39 (03) : 105 - 114
  • [28] TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes
    Ongchai, Siriwan
    Somnoo, Oraphan
    Kongdang, Patiwat
    Peansukmanee, Siriporn
    Tangyuenyong, Siriwan
    JOURNAL OF VETERINARY SCIENCE, 2018, 19 (06) : 735 - 743
  • [29] Oncostatin M (OSM) stimulates resorption and inhibits synthesis of proteoglycan in porcine articular cartilage explants
    Hui, W
    Bell, M
    Carroll, G
    CYTOKINE, 1996, 8 (06) : 495 - 500
  • [30] Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth
    Hyttinen, Mika M.
    Holopainen, Jaakko
    van Weeren, P. Rene
    Firth, Elwyn C.
    Helminen, Heikki J.
    Brama, Pieter A. J.
    JOURNAL OF ANATOMY, 2009, 215 (05) : 584 - 591
12345