A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation

被引：217

作者：

Widegren, Magnus B. ^{[1
]}

Harkness, Gavin J. ^{[1
]}

Slawin, Alexandra M. Z. ^{[1
]}

Cordes, David B. ^{[1
]}

Clarke, Matthew L. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

enantioselective catalysis; ester hydrogenation; ferrocene; manganese; reduction; ASYMMETRIC ALKENE HYDROGENATION; CHIRAL TRIDENTATE LIGAND; CARBOXYLIC-ACID ESTERS; C-H ACTIVATION; PINCER COMPLEXES; SELECTIVE HYDROGENATION; IRIDIUM CATALYSTS; RUTHENIUM COMPLEX; AROMATIC KETONES; COBALT CATALYST;

D O I：

10.1002/anie.201702406

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anew hydrogenation catalyst based onamanganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 degrees C.

引用

页码：5825 / 5828

页数：4

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