Immunology and the elusive AIDS vaccine

被引：130

作者：

Virgin, Herbert W. ^{[1
,2
]}

Walker, Bruce D. ^{[3
,4
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Midwest Reg Ctr Excellence Biodef & Emerging Infe, St Louis, MO 63110 USA

[3] Massachusetts Gen Hosp, MIT, Ragon Inst, Charlestown, MA 02129 USA

[4] Harvard Univ, Howard Hughes Med Inst, Charlestown, MA 02129 USA

来源：

NATURE | 2010年 / 464卷 / 7286期

基金：

美国国家卫生研究院;

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL RESPONSES; HIV-1; INFECTION; NEUTRALIZING ANTIBODIES; LYMPHOCYTE ESCAPE; IMMUNE CONTROL; MACAQUE MODEL; B-CELLS; REPLICATION; PROTECTION;

D O I：

10.1038/nature08898

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this goal is achievable. Natural immunity is not protective, and despite immunogenicity of HIV vaccine candidates, human trials have exclusively yielded disappointing results. Nevertheless, there is an indication that success may be possible, but this will be dependent on understanding the antiviral immune response in unprecedented depth to identify and engineer the types of immunity required. Here we outline fundamental immunological questions that need to be answered to develop a protective HIV vaccine, and the immediate need to harness a much broader scientific community to achieve this goal.

引用

页码：224 / 231

页数：8

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