Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

被引：38

作者：

Barbera-Cremades, Maria ^{[1
]}

Baroja-Mazo, Alberto ^{[1
]}

Pelegrin, Pablo ^{[1
]}

机构：

[1] Hosp Clin Univ Virgen de la Arrixaca IMIB Arrixac, Inst Murciano Invest Biosanitaria, Ctr Invest Biomed Red Area Temat Enfermedades Hep, Unidad Inflamac Mol & Cirugia Expt, Murcia, Spain

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2016年 / 99卷 / 02期

基金：

欧洲研究理事会;

关键词：

adenosine; Ym1; extracellular ATP; purinergic receptors; adenosine receptors; NUCLEOTIDE RECEPTORS; ADENOSINE; YM1; EXPRESSION; MONOCYTE; MURINE; POLARIZATION; RELEASE; PROTEIN; GAMMA;

D O I：

10.1189/jlb.1A0514-267RR

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macrophages represent a highly heterogenic cell population of the innate immune system, with important roles in the initiation and resolution of the inflammatory response. Purinergic signaling regulates both M1 and M2 macrophage function at different levels by controlling the secretion of cytokines, phagocytosis, and the production of reactive oxygen species. We found that extracellular nucleotides arrest macrophage differentiation from bone marrow precursors via adenosine and P2 receptors. This results in a mature macrophage with increased expression of M2, but not M1, genes. Similar to adenosine and ATP, macrophage growth arrested with LPS treatment resulted in an increase of the M2-related marker Ym1. Recombinant Ym1 was able to affect macrophage proliferation and could, potentially, be involved in the arrest of macrophage growth during hematopoiesis.

引用

页码：289 / 299

页数：11

共 51 条

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