3-Carboxy-2,2,5,5-tetra(2H3)methyl-[4-2H (1H)]-3-pyrroline-(1-15N)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging

被引：11

作者：

Shundrin, Leonid A. ^{[1
,2
,3
]}

Kirilyuk, Igor A. ^{[1
,2
]}

Grigor'ev, Igor A. ^{[1
,4
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

[3] Sci Inst Clin & Expt Lymphol, Novosibirsk 630060, Russia

[4] EN Meshalkin State Res Inst Circulat Pathol, Novosibirsk 630055, Russia

来源：

MENDELEEV COMMUNICATIONS | 2014年 / 24卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

NITROXIDES; REDUCTION; ASCORBATE;

D O I：

10.1016/j.mencom.2014.09.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The suitability of 3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl and its non-deuterated N-14-containing nitroxide analogue for L-band EPR in vivo imaging has been demonstrated. Both nitroxides exhibit low rates of reduction with ascorbate and slow decay in mice blood and plasma and, according to the EPR data, accumulate in the liver of a living mice within 10-70 min after the injection via tail vein, and then collect in the bladder.

引用

页码：298 / 300

页数：3

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