3-Carboxy-2,2,5,5-tetra(2H3)methyl-[4-2H (1H)]-3-pyrroline-(1-15N)-1-oxyl as a spin probe for in vivo L-band electron paramagnetic resonance imaging

被引：11

作者：

Shundrin, Leonid A. ^{[1
,2
,3
]}

Kirilyuk, Igor A. ^{[1
,2
]}

Grigor'ev, Igor A. ^{[1
,4
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Dept Nat Sci, Novosibirsk 630090, Russia

[3] Sci Inst Clin & Expt Lymphol, Novosibirsk 630060, Russia

[4] EN Meshalkin State Res Inst Circulat Pathol, Novosibirsk 630055, Russia

来源：

MENDELEEV COMMUNICATIONS | 2014年 / 24卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

NITROXIDES; REDUCTION; ASCORBATE;

D O I：

10.1016/j.mencom.2014.09.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The suitability of 3-Carboxy-2,2,5,5-tetra(H-2(3))methyl-[4-H-2 (H-1)]-3-pyrroline-(1-N-15)-1-oxyl and its non-deuterated N-14-containing nitroxide analogue for L-band EPR in vivo imaging has been demonstrated. Both nitroxides exhibit low rates of reduction with ascorbate and slow decay in mice blood and plasma and, according to the EPR data, accumulate in the liver of a living mice within 10-70 min after the injection via tail vein, and then collect in the bladder.

引用

收藏

页码：298 / 300

页数：3

相关论文

共 15 条

[1] Reversible reduction of nitroxides to hydroxylamines: Roles for ascorbate and glutathione [J].

Bobko, Andrey A. ;

Kirilyuk, Igor A. ;

Grigor'ev, Igor A. ;

Zweier, Jav L. ;

Khramtsov, Valery V. .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (03) :404-412

[2] 2H,15N-Substituted Nitroxides as Sensitive Probes for Electron Paramagnetic Resonance Imaging [J].

Burks, Scott R. ;

Bakhshai, Justin ;

Makowsky, Mallory A. ;

Muralidharan, Sukumaran ;

Tsai, Pei ;

Rosen, Gerald M. ;

Kao, Joseph P. Y. .

JOURNAL OF ORGANIC CHEMISTRY, 2010, 75 (19) :6463-6467

[3] SIMULATION OF MULTIPLE ISOTROPIC SPIN-TRAP EPR-SPECTRA [J].

DULING, DR .

JOURNAL OF MAGNETIC RESONANCE SERIES B, 1994, 104 (02) :105-110

[4] IMAGING RADIO-FREQUENCY ELECTRON-SPIN-RESONANCE SPECTROMETER WITH HIGH-RESOLUTION AND SENSITIVITY FOR INVIVO MEASUREMENTS [J].

HALPERN, HJ ;

SPENCER, DP ;

VANPOLEN, J ;

BOWMAN, MK ;

NELSON, AC ;

DOWEY, EM ;

TEICHER, BA .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1989, 60 (06) :1040-1050

[5] OXYMETRY DEEP IN TISSUES WITH LOW-FREQUENCY ELECTRON-PARAMAGNETIC-RESONANCE [J].

HALPERN, HJ ;

YU, C ;

PERIC, M ;

BARTH, E ;

GRDINA, DJ ;

TEICHER, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :13047-13051

[6]

Haney CR, 2006, MOL IMAGING, V5, P175

[7]

KEANA JFW, 1984, PHYSIOL CHEM PHYS ME, V16, P477

[8]

Khramtsov VV, 2012, NITROXIDES - THEORY, EXPERIMENT AND APPLICATIONS, P317, DOI 10.5772/39129

[9]

Khramtsov VV., 1998, BIO MAGN RE, V14, P109

[10] Synthesis of 2,5-Bis(spirocyclohexane)-Substituted Nitroxides of Pyrroline and Pyrrolidine Series, Including Thiol-Specific Spin Label: An Analogue of MTSSL with Long Relaxation Time [J].

Kirilyuk, Igor A. ;

Polienko, Yuliya F. ;

Krumkacheva, Olesya A. ;

Strizhakov, Rodion K. ;

Gatilov, Yurii V. ;

Grigor'ev, Igor A. ;

Bagryanskaya, Elena G. .

JOURNAL OF ORGANIC CHEMISTRY, 2012, 77 (18) :8016-8027