Crystal structures, electrochemical properties, antioxidant screening and in vitro cytotoxic studies on four novel Cu(II) complexes of bidentate Schiff base ligands derived from 2-methoxyethylamine

被引:28
作者
Abbasi, Zeinab [1 ]
Salehi, Mehdi [1 ]
Kubicki, Maciej [2 ]
Khaleghian, Ali [3 ]
机构
[1] Semnan Univ, Dept Chem, Semnan, Iran
[2] Adam Mickiewicz Univ, Fac Chem, Poznan, Poland
[3] Semnan Univ Med Sci, Dept Biochem, Fac Med, Semnan, Iran
关键词
Crystal structure; radical scavenging; MTT assay; anti-cancer activity; electrochemical properties; TRANSITION-METAL-COMPLEXES; COPPER(II) COMPLEXES; ANTICANCER ACTIVITY; DNA CLEAVAGE; UREASE INHIBITION; HYDROGEN-PEROXIDE; ZN(II) COMPLEXES; BSA-BINDING; NI(II); ANTIBACTERIAL;
D O I
10.1080/00958972.2017.1323082
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Four novel Schiff base ligands and their copper(II) complexes, [Cu(L-1)(2)] (1), [Cu(L-2)(2)] (2), [Cu(L-3)(2)] (3), and [Cu(L-4)(2)] (4), were synthesized and characterized by elemental analyses, FT-IR, and UV-Vis spectroscopy. The ligands were synthesized from the condensation of 2-methoxyethylamine with various salicylaldehyde derivatives (x-salicylaldehyde for HLn, x=H (n=1), 5-Br (n=2), 3-OMe (n=3), and 4-OMe (n=4)). The molecular structures of 1, 2, and 3 were determined by the single crystal X-ray diffraction technique. The redox behavior studies of the complexes in acetonitrile display the electronic effects of the groups on the redox potential. The antioxidant activity of the Schiff base ligands and their Cu(II) complexes was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and FRAP assay. Furthermore, the in vitro anticancer activity of compounds was screened, including MTT and migration assays against gastriccancer cell line (MKN-45). The results show that all ligands and complexes have antioxidant and anticancer activity in a concentration-dependent way. [GRAPHICS] .
引用
收藏
页码:2074 / 2093
页数:20
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