Metabolic Risk Factors of Alzheimer's Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study

被引:16
作者
Cheng, Chih-Kuang [1 ,2 ]
Tsao, Yu-Chien [3 ,4 ,5 ]
Su, Yuan-Chih [6 ,7 ]
Sung, Fung-Chang [8 ]
Tai, Hsu-Chih [9 ]
Kung, Woon-Man [9 ,10 ,11 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp & Coll Med, Linkou Med Ctr, Stroke Ctr, Taoyuan, Taiwan
[2] Chang Gung Univ, Chang Gung Mem Hosp & Coll Med, Linkou Med Ctr, Dept Neurol, Taoyuan, Taiwan
[3] Yonghe Cardinal Tien Hosp, Dept Internal Med, Taipei, Taiwan
[4] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, Taipei, Taiwan
[5] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan
[6] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[7] China Med Univ, Coll Med, Taichung, Taiwan
[8] China Med Univ, Dept Publ Hlth, Taichung, Taiwan
[9] Chinese Culture Univ, Dept Exercise & Hlth Promot, Coll Educ, Taipei, Taiwan
[10] Buddhist Tzu Chi Med Fdn, Div Neurosurg, Dept Surg, Taipei Tzu Chi Hosp, New Taipei, Taiwan
[11] Buddhist Tzu Chi Univ, Sch Med, Dept Surg, Hualien, Taiwan
关键词
COGNITIVE DECLINE; CEREBRAL MICROBLEEDS; CEREBROVASCULAR LESIONS; APOLIPOPROTEIN-E; ATHEROSCLEROSIS; PREVALENCE; IMPACT; BETA; DIAGNOSIS;
D O I
10.1155/2018/8312346
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background. Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) share many risk factors. Evidence suggests that metabolic risk factors are important to AD; however, their association with DLB is unclear. The risk of cardiovascular diseases (CVD) associated with AD and DLB is also uncertain. Thus, this nationwide, population-based study was designed to evaluate the metabolic and CVD risks in AD and DLB. Materials and Methods. Data were obtained from the Taiwan National Health Insurance Research Database. AD patients, DLB patients, and normal control (NC) individuals from 1996 to 2013 were enrolled for risk assessment. Results. In total, 7544 NC individuals, 1324 AD patients, and 562 DLB patients were enrolled. Participants with one or more metabolic risk factors had significantly higher odds of AD or DLB. No significant differences in metabolic risk factors were observed between DLB and AD patients. AD patients had a lower risk of CVD (aHR = 0.67, 95% CI = 0.59-0.76, p value < 0.001) and coronary artery disease (CAD) (aHR = 0.59, 95% CI = 0.51-0.69, p value < 0.001) than NC. DLB patients had a higher risk of ischemic stroke (aHR = 2.27, 95% CI = 1.68-3.06, p value < 0.001) than NC. Conclusion. Metabolic risk factors are important in AD and DLB. Patients with AD might have a lower risk of CAD and ischemic strokes. Patients with DLB might have a higher risk of ischemic stroke.
引用
收藏
页数:8
相关论文
共 34 条
[1]   Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization [J].
Ahn, Hyung Jin ;
Zamolodchikov, Daria ;
Cortes-Canteli, Marta ;
Norris, Erin H. ;
Glickman, J. Fraser ;
Strickland, Sidney .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (50) :21812-21817
[2]   The overlap between vascular disease and Alzheimer's disease - lessons from pathology [J].
Attems, Johannes ;
Jellinger, Kurt A. .
BMC MEDICINE, 2014, 12
[3]   Impact of coronary heart disease on cognitive decline in Alzheimer's disease: a prospective longitudinal cohort study in primary care [J].
Bleckwenn, Markus ;
Kleineidam, Luca ;
Wagner, Michael ;
Jessen, Frank ;
Weyerer, Siegfried ;
Werle, Jochen ;
Wiese, Birgitt ;
Luehmann, Dagmar ;
Posselt, Tina ;
Koenig, Hans-Helmut ;
Brettschneider, Christian ;
Moesch, Edelgard ;
Weeg, Dagmar ;
Fuchs, Angela ;
Pentzek, Michael ;
Luck, Tobias ;
Riedel-Heller, Steffi G. ;
Maier, Wolfgang ;
Scherer, Martin .
BRITISH JOURNAL OF GENERAL PRACTICE, 2017, 67 (655) :E111-E117
[4]   Risk factors for dementia with Lewy bodies A case-control study [J].
Boot, Brendon P. ;
Orr, Carolyn F. ;
Ahlskog, J. Eric ;
Ferman, Tanis J. ;
Roberts, Rosebud ;
Pankratz, Vernon S. ;
Dickson, Dennis W. ;
Parisi, Joseph ;
Aakre, Jeremiah A. ;
Geda, Yonas E. ;
Knopman, David S. ;
Petersen, Ronald C. ;
Boeve, Bradley F. .
NEUROLOGY, 2013, 81 (09) :833-840
[5]   Comorbidity and dementia: A nationwide survey in Taiwan [J].
Chen, Ting-Bin ;
Yiao, Szu-Yu ;
Sun, Yu ;
Lee, Huey-Jane ;
Yang, Shu-Chien ;
Chiu, Ming-Jang ;
Chen, Ta-Fu ;
Lin, Ker-Neng ;
Tang, Li-Yu ;
Lin, Chung-Chih ;
Wang, Pei-Ning .
PLOS ONE, 2017, 12 (04)
[6]   Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution [J].
Chiang, G. C. ;
Hernandez, J. C. Cruz ;
Kantarci, K. ;
Jack, C. R., Jr. ;
Weiner, M. W. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2015, 36 (09) :1635-1641
[7]   Prevalence of small cerebral bleeds in patients with a neurodegenerative dementia: A neuropathological study [J].
De Reuck, Jacques ;
Deramecourt, Vincent ;
Cordonnier, Charlotte ;
Leys, Didier ;
Pasquier, Florence ;
Maurage, Claude-Alain .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2011, 300 (1-2) :63-66
[8]   A clinicopathological approach to the diagnosis of dementia [J].
Elahi, Fanny M. ;
Miller, Bruce L. .
NATURE REVIEWS NEUROLOGY, 2017, 13 (08) :457-476
[9]  
Gillette-Guyonnet S, 2000, AM J CLIN NUTR, V71, p637S
[10]   Immune attack: the role of inflammation in Alzheimer disease [J].
Heppner, Frank L. ;
Ransohoff, Richard M. ;
Becher, Burkhard .
NATURE REVIEWS NEUROSCIENCE, 2015, 16 (06) :358-372