Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease

被引：82
作者：
Burns, Jessie L. [1 ]
Nakamura, Manabu T. [2 ]
Ma, David W. L. [1 ]
机构：
[1] Univ Guelph, Dept Human Hlth & Nutr Sci, 50 Stone Rd East, Guelph, ON N1G 2W1, Canada
[2] Univ Illinois, Dept Food Sci & Human Nutr, Chicago, IL USA
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2018年 / 135卷
关键词：
Linoleic acid (LA); Arachidonic acid (AA); Inflammation; Cardiovascular health; Liver health; Cancer; POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; KILLER-CELL ACTIVITY; SERUM-LIPID LEVELS; CANCER-RISK; COLORECTAL-CANCER; N-6; INFLAMMATION; PROSTATE; RATIO;
D O I：
10.1016/j.plefa.2018.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dietary fatty acids are associated with the development of many chronic diseases, such as obesity, diabetes, cardiovascular disease, metabolic syndrome, and several cancers. This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. The evidence suggests that a pro-inflammatory view of LA and AA may be over simplified. Overall, this review highlights gaps in our understanding of the biological roles of LA, AA and their complex relationship with n-3 PUFA and the need for future studies that examine the roles of individual fatty acids, rather than groups.
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页码：1 / 4
页数：4
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