Preparation of porous organically-modified silicate hybrids cell culture matrix

被引：3

作者：

Tsuru, K. ^{[1
]}

Hayakawa, S. ^{[1
]}

Shirosaki, Y. ^{[1
]}

Okayama, T. ^{[1
]}

Kataoka, K. ^{[2
]}

Huh, N-H. ^{[2
]}

Osaka, A. ^{[1
]}

机构：

[1] Okayama Univ, Biomat Lab, Grad Sch Nat Sci & Technol, Okayama 7008530, Japan

[2] Okayama Univ, Dept Cell Biol Grad Sch Med Dent & Pharmacol Sci, Okayama 7008558, Japan

来源：

BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷

关键词：

scaffolds; inorganic-organic hybrids; bioreactor; cell culture; HepG2;

D O I：

10.4028/www.scientific.net/KEM.330-332.1177

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane(PDMS) through a sol-gel route using sieved sucruse granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 mu m. In the three-dimensional cell culture, mammalien cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

引用

页码：1177 / +

页数：3