Cinnamaldehydes in Cancer Chemotherapy

被引：106
作者：
Hong, Su-Hyung [1 ]
Ismail, Ismail Ahmed [1 ,3 ]
Kang, Sung-Min [1 ]
Han, Dong Cho [2 ]
Kwon, Byoung-Mog [2 ]
机构：
[1] Kyungpook Natl Univ, Sch Dent, Dept Oral Microbiol & Immunol, Daegu 700412, South Korea
[2] Univ Sci & Technol Korea, Korea Res Inst Biosci & Biotechnol, Lab Chem Biol & Genom, 125 Gwahakro Yoosunggu, Daejeon 305806, South Korea
[3] Assiut Univ, Fac Sci, Dept Zool, Mol Cell Biol Lab, Assiut 71516, Egypt
来源：
PHYTOTHERAPY RESEARCH | 2016年 / 30卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
cinnamaldehyde; 2-hydroxycinnamaldehyde; 2-benzoyloxycinnamaldehyde; cancer chemotherapy; apoptosis; AQUEOUS CINNAMON EXTRACT; CELL-CYCLE PROGRESSION; UP-REGULATION; IN-VITRO; BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; INDUCED APOPTOSIS; NATURAL-PRODUCT; DOWN-REGULATION; TUMOR-GROWTH;
D O I：
10.1002/ptr.5592
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright (c) 2016 John Wiley & Sons, Ltd.
引用
收藏
页码：754 / 767
页数：14
相关论文
共 98 条
[1]   Cinnamic aldehyde suppresses hypoxia-induced angiogenesis via inhibition of hypoxia-inducible factor-1α expression during tumor progression [J].
Bae, Woom-Yee ;
Choi, Jae-Sun ;
Kim, Ja-Eun ;
Jeong, Joo-Won .
BIOCHEMICAL PHARMACOLOGY, 2015, 98 (01) :41-50
[2]   Tumor necrosis factor or tumor promoting factor? [J].
Balkwill, F .
CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (02) :135-141
[3]   Cinnamic acids as new inhibitors of 17β-hydroxy steroid dehydrogenase type 5 (AKR1C3) [J].
Brozic, P ;
Golob, B ;
Gomboc, N ;
Rizner, TL ;
Gobec, S .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 248 (1-2) :233-235
[4]   Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 [J].
Brozic, Petra ;
Kocbek, Petra ;
Sova, Matej ;
Kristl, Julijana ;
Martens, Stefan ;
Adamski, Jerzy ;
Gobec, Stanislav ;
Rizner, Tea Lanisnik .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2009, 301 (1-2) :229-234
[5]   The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth [J].
Cabello, Christopher M. ;
Bair, Warner B., III ;
Lamore, Sarah D. ;
Ley, Stephanie ;
Bause, Alexandra S. ;
Azimian, Sara ;
Wondrak, Georg T. .
FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (02) :220-231
[6]   In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix [J].
Cheng, Diana M. ;
Kuhn, Peter ;
Poulev, Alexander ;
Rojo, Leone E. ;
Lila, Mary Ann ;
Raskin, Ilya .
FOOD CHEMISTRY, 2012, 135 (04) :2994-3002
[7]   Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention [J].
Chew, Eng-Hui ;
Nagle, Amrita A. ;
Zhang, Yaochun ;
Scarmagnani, Silvia ;
Palaniappan, Puvithira ;
Bradshaw, Tracey D. ;
Holmgren, Arne ;
Westwell, Andrew D. .
FREE RADICAL BIOLOGY AND MEDICINE, 2010, 48 (01) :98-111
[8]  
Cho SY., 2013, Evidence-based complementary and alternative medicine : eCAM, V2013, P974313, DOI [10.1155/2013/974313., DOI 10.1155/2013/974313]
[9]   Clinicopathological significance of PTEN loss and the phosphoinositide 3-kinase/Akt pathway in sporadic colorectal neoplasms:: is PTEN loss predictor of local recurrence? [J].
Colakoglu, Tamer ;
Yildirim, Sedat ;
Kayaselcuk, Fazilet ;
Nursal, Tarik Zafer ;
Ezer, Ali ;
Noyan, Turgut ;
Karakayali, Hamdi ;
Haberal, Mehmet .
AMERICAN JOURNAL OF SURGERY, 2008, 195 (06) :719-725
[10]   Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival [J].
Cullinan, SB ;
Zhang, D ;
Hannink, M ;
Arvisais, E ;
Kaufman, RJ ;
Diehl, JA .
MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) :7198-7209
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