Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright (c) 2016 John Wiley & Sons, Ltd.
机构:
Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Bae, Woom-Yee
;
Choi, Jae-Sun
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Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Choi, Jae-Sun
;
Kim, Ja-Eun
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Kyung Hee Univ, Sch Med, Dept Pharmacol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kim, Ja-Eun
;
Jeong, Joo-Won
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Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
机构:
Univ Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Brozic, Petra
;
Kocbek, Petra
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Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Kocbek, Petra
;
Sova, Matej
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Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Sova, Matej
;
Kristl, Julijana
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Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Kristl, Julijana
;
Martens, Stefan
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Univ Marburg, Inst Pharmazeut Biol, D-35037 Marburg, GermanyUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Martens, Stefan
;
Adamski, Jerzy
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German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Expt Genet, D-85764 Neuherberg, GermanyUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Adamski, Jerzy
;
Gobec, Stanislav
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Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Gobec, Stanislav
;
Rizner, Tea Lanisnik
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Univ Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
机构:
Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Bae, Woom-Yee
;
Choi, Jae-Sun
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h-index: 0
机构:
Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Choi, Jae-Sun
;
Kim, Ja-Eun
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Med, Dept Pharmacol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kim, Ja-Eun
;
Jeong, Joo-Won
论文数: 0引用数: 0
h-index: 0
机构:
Kyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
Kyung Hee Univ, Sch Med, Dept Anat & Neurobiol, Seoul 130701, South KoreaKyung Hee Univ, Sch Med, Dept Biomed Sci, Seoul 130701, South Korea
机构:
Univ Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Brozic, Petra
;
Kocbek, Petra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Kocbek, Petra
;
Sova, Matej
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Sova, Matej
;
Kristl, Julijana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Kristl, Julijana
;
Martens, Stefan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Marburg, Inst Pharmazeut Biol, D-35037 Marburg, GermanyUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Martens, Stefan
;
Adamski, Jerzy
论文数: 0引用数: 0
h-index: 0
机构:
German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Expt Genet, D-85764 Neuherberg, GermanyUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Adamski, Jerzy
;
Gobec, Stanislav
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h-index: 0
机构:
Univ Ljubljana, Fac Pharm, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia
Gobec, Stanislav
;
Rizner, Tea Lanisnik
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, SloveniaUniv Ljubljana, Fac Med, Dept Biochem, Ljubljana 61000, Slovenia