Two new benzolactones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities

被引：14

作者：

Shen, Qinpeng ^{[1
]}

Xu, Xingmeng ^{[1
,2
,3
]}

Zhang, Fengmei ^{[1
]}

Xiang, Nengjun ^{[1
]}

He, Pei ^{[1
]}

Si, Xiaoxi ^{[1
]}

Zhu, Ruizhi ^{[1
]}

Wang, Kunmiao ^{[1
]}

Liu, Zhihua ^{[1
]}

Liu, Chunbo ^{[1
]}

Miao, Mingming ^{[1
]}

机构：

[1] China Tobacco Yunnan Ind Co Ltd, Key Lab Tobacco Chem Yunnan Prov, Kunming, Peoples R China

[2] Kunming Med Univ, Sch Pharmaceut Sci, Kunming, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Nicotiana tabacum; benzolactones; anti-tobacco mosaic virus activities; PHENOLIC-COMPOUNDS; ORIENTAL TOBACCO; DERIVATIVES; CYTOTOXICITY; SESQUITERPENE; ROOTS; STEMS;

D O I：

10.1080/14786419.2015.1104675

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3-6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1-6 exhibited high anti-TMV activities with inhibition rates in the range of 16.9-26.2%, respectively. [GRAPHICS] .

引用

页码：1464 / 1469

页数：6

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