Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis

被引:41
作者
Mari-Alexandre, Josep [1 ]
Carcelen, Antonio Pellin [2 ]
Agababyan, Cristina [1 ,3 ]
Moreno-Manuel, Andrea [4 ,5 ]
Garcia-Oms, Javier [1 ,3 ]
Calabuig-Farinas, Silvia [4 ,5 ,6 ,7 ]
Gilabert-Estelles, Juan [1 ,3 ,8 ]
机构
[1] Fdn Hosp Gen Univ Valencia, Res Lab Biomarkers Reprod Gynaecol & Obstet, Valencia 46014, Spain
[2] Univ Valencia, Dept Physiol, Valencia 46010, Spain
[3] Consorcio Hosp Gen Univ Valencia, Comprehens Multidisciplinary Endometriosis Unit, Valencia 46014, Spain
[4] Fdn Invest Hosp Gen Univ Valencia, Mol Oncol Lab, Valencia 46014, Spain
[5] Fdn Invest Hosp Gen Univ Valencia, Ctr Invest Principe Felipe, TRIAL Mixed Unit, Valencia 46014, Spain
[6] Univ Valencia, Dept Pathol, Valencia 46010, Spain
[7] Ctr Invest Biomed Red Canc CIBERONC, Valencia 46014, Spain
[8] Univ Valencia, Dept Paediat Obstet & Gynaecol, Valencia 46010, Spain
关键词
oxidative stress; miRNAs; endometriosis; high-grade serous ovarian cancer; endometriosis-associated ovarian cancer; epithelial-to-mesenchymal transition; chemoresistance; CLEAR-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; SERUM MICRORNA; INHIBITS PROLIFERATION; CIRCULATING MICRORNAS; EXPRESSION PROFILE; MOLECULAR-CHANGES; PERITONEAL-FLUID; REDOX REGULATION; MIRNA LANDSCAPE;
D O I
10.3390/ijms20215322
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19-22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC.
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页数:24
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