Do astrocytes really exocytose neurotransmitters?

被引：510

作者：

Hamilton, Nicola B. ^{[1
]}

Attwell, David ^{[1
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2010年 / 11卷 / 04期

基金：

英国惠康基金; 欧洲研究理事会;

关键词：

DEPENDENT GLUTAMATE RELEASE; LONG-TERM POTENTIATION; KISS-AND-RUN; D-SERINE; PLASMA-MEMBRANE; NEURONAL-ACTIVITY; IN-SITU; VESICULAR GLUTAMATE; CALCIUM WAVES; ATP RELEASE;

D O I：

10.1038/nrn2803

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the past 20 years, an extra layer of information processing, in addition to that provided by neurons, has been proposed for the CNS. Neuronally evoked increases of the intracellular calcium concentration in astrocytes have been suggested to trigger exocytotic release of the 'gliotransmitters' glutamate, ATP and D-serine. These are proposed to modulate neuronal excitability and transmitter release, and to have a role in diseases as diverse as stroke, epilepsy, schizophrenia, Alzheimer's disease and HIV infection. However, there is intense controversy about whether astrocytes can exocytose transmitters in vivo. Resolving this issue would considerably advance our understanding of brain function.

引用

页码：227 / 238

页数：12

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