Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer's Disease

被引：8

作者：

Xu, Xin ^{[1
,2
]}

Ruan, Xiangyan ^{[1
,2
,3
,4
]}

Ju, Rui ^{[1
,2
]}

Wang, Zhikun ^{[1
,2
]}

Yang, Yu ^{[1
,2
]}

Cheng, Jiaojiao ^{[1
,2
]}

Gu, Muqing ^{[1
,2
]}

Mueck, Alfred O. ^{[1
,2
,3
,4
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Gynecol Endocrinol, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China

[2] Beijing Maternal & Child Hlth Care Hosp, Beijing, Peoples R China

[3] Univ Tubingen, Res Ctr Womens Hlth, Tubingen, Germany

[4] Univ Tubingen, Univ Womens Hosp Tuebingen, Tubingen, Germany

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2022年 / 37卷

关键词：

alzheimer's disease; cerebral amyloid angiopathy; endothelia cell; progesterone receptor membrane component-1; PROTEIN;

D O I：

10.1177/15333175221109749

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Cerebrovascular changes occur in Alzheimer's disease (AD). The progesterone receptor membrane component-1 (PGRMC1) is a well identified hormone receptor with multiple functions in AD. This study aims to explore the involvement of PGRMC1 in the regulation of vascular endothelial function, providing new therapy options for AD. Single-cell sequencing revealed that the expression of PGRMC1 is lower in AD. By bioinformatics analysis, we found PGRMC1 was associated with regulation of cell proliferation, angiogenesis and etc. To understand the functional significance of PGRMC1, knockdown and overexpression were performed using human brain microvascular endothelial cells (HBMVECs), respectively. Cell proliferation assay, migration assay, tube formation assay were performed in experiments. We demonstrated that the overexpression of PGRMC1 promoted the cellular processes associated with endothelia cell proliferation, migration, and angiogenesis, significantly. In conclusion, PGRMC1 may contribute to the modulation of HBMVECs function in AD. This finding may offer novel targets for AD treatment.

引用

页数：9

共 24 条

[1] Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease [J].

Apatiga-Perez, Ricardo ;

Soto-Rojas, Luis O. ;

Campa-Cordoba, B. Berenice ;

Luna-Viramontes, Nabil Itzi ;

Cuevas, Elvis ;

Villanueva-Fierro, Ignacio ;

Ontiveros-Torres, Miguel Angel ;

Bravo-Munoz, Marely ;

Flores-Rodriguez, Paola ;

Garces-Ramirez, Linda ;

de la Cruz, Fidel ;

Montiel-Sosa, Jose Francisco ;

Pacheco-Herrero, Mar ;

Luna-Munoz, Jose .

METABOLIC BRAIN DISEASE, 2022, 37 (01) :39-50

[2] Vasoprotective Functions of High-Density Lipoproteins Relevant to Alzheimer's Disease Are Partially Conserved in Apolipoprotein B-Depleted Plasma [J].

Button, Emily B. ;

Gilmour, Megan ;

Cheema, Harleen K. ;

Martin, Emma M. ;

Agbay, Andrew ;

Robert, Jerome ;

Wellington, Cheryl L. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (03)

[3] Genetics of ovarian insufficiency and defects of folliculogenesis [J].

Franca, Monica Malheiros ;

Mendonca, Berenice Bilharinho .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 36 (01)

[4] Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer's disease [J].

Franzmeier, Nicolai ;

Dewenter, Anna ;

Frontzkowski, Lukas ;

Dichgans, Martin ;

Rubinski, Anna ;

Neitzel, Julia ;

Smith, Ruben ;

Strandberg, Olof ;

Ossenkoppele, Rik ;

Buerger, Katharina ;

Duering, Marco ;

Hansson, Oskar ;

Ewers, Michael .

SCIENCE ADVANCES, 2020, 6 (48)

[5] Amyloidosis Associated with Cerebral Amyloid Angiopathy: Cell Signaling Pathways Elicited in Cerebral Endothelial Cells [J].

Ghiso, Jorge ;

Fossati, Silvia ;

Rostagno, Agueda .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 42 :S167-S176

[6] Progesterone receptor membrane component 1 is involved in oral cancer cell metastasis [J].

Huang, Hsun-Yu ;

Chou, Hsiu-Chuan ;

Law, Ching-Hsuan ;

Chang, Wan-Ting ;

Wen, Tzu-Ning ;

Liao, En-Chi ;

Lin, Meng-Wei ;

Lin, Li-Hsun ;

Wei, Yu-Shan ;

Tsai, Yi-Ting ;

Chen, Hsin-Yi ;

Tan, Kui-Thong ;

Kuo, Wen-Hung ;

Ko, Mei-Lan ;

Chang, Shing-Jyh ;

Lee, Ying-Ray ;

Chan, Hong-Lin .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 (17) :9737-9751

[7] Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits [J].

Izzo, Nicholas J. ;

Staniszewski, Agnes ;

To, Lillian ;

Fa, Mauro ;

Teich, Andrew F. ;

Saeed, Faisal ;

Wostein, Harrison ;

Walko, Thomas, III ;

Vaswani, Anisha ;

Wardius, Meghan ;

Syed, Zanobia ;

Ravenscroft, Jessica ;

Mozzoni, Kelsie ;

Silky, Colleen ;

Rehak, Courtney ;

Yurko, Raymond ;

Finn, Patricia ;

Look, Gary ;

Rishton, Gilbert ;

Safferstein, Hank ;

Miller, Miles ;

Johanson, Conrad ;

Stopa, Edward ;

Windisch, Manfred ;

Hutter-Paier, Birgit ;

Shamloo, Mehrdad ;

Arancio, Ottavio ;

LeVine, Harry, III ;

Catalano, Susan M. .

PLOS ONE, 2014, 9 (11)

[8] Alzheimer's Therapeutics Targeting Amyloid Beta 1-42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity [J].

Izzo, Nicholas J. ;

Xu, Jinbin ;

Zeng, Chenbo ;

Kirk, Molly J. ;

Mozzoni, Kelsie ;

Silky, Colleen ;

Rehak, Courtney ;

Yurko, Raymond ;

Look, Gary ;

Rishton, Gilbert ;

Safferstein, Hank ;

Cruchaga, Carlos ;

Goate, Alison ;

Cahill, Michael A. ;

Arancio, Ottavio ;

Mach, Robert H. ;

Craven, Rolf ;

Head, Elizabeth ;

LeVine, Harry, III ;

Spires-Jones, Tara L. ;

Catalano, Susan M. .

PLOS ONE, 2014, 9 (11)

[9] Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang [J].

Jin, Jingyun ;

Chen, Bin ;

Zhan, Xiangyang ;

Zhou, Zhiyi ;

Liu, Hui ;

Dong, Yun .

PLOS ONE, 2021, 16 (06)

[10] Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease [J].

Kalaria, Rajesh N. ;

Sepulveda-Falla, Diego .

AMERICAN JOURNAL OF PATHOLOGY, 2021, 191 (11) :1888-1905

← 1 2 3 →