New Potent DPPH Radical Scavengers from a Marine-Derived Actinomycete Strain USF-TC31

被引：19

作者：

Sugiyama, Yasumasa ^{[1
]}

Hirota, Akira ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Lab Appl Microbiol, Suruga Ku, Shizuoka 4228526, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 12期

关键词：

DPPH radical scavenger; structural elucidation; marine-derived actinomycete; NATURAL-PRODUCTS; FUNGUS; ANTIOXIDANT; BACTERIA; RESOURCE;

D O I：

10.1271/bbb.90636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six compounds were isolated as radical scavengers from the culture broth of a marine-derived actinomycete strain USF-TC31. The structures of two novel compounds were determined to be those of N-carbamoyl-2,3-dihydroxybenzamide (5) and 2-acetamido-3-(2,3-dihydroxybenzoylthio)propanoic acid (6), and four known compounds were identified to be anthranilic acid (1), 2,3-dihydroxybenzoic acid (2), 2,3-dihydroxybenzamide (3) and benadrostin (4) on the basis of spectroscopic data. Compound 6 was characterized as a racemate by its specific rotation. Each of the obtained compounds was evaluated for DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, and compounds 2, 3, 5 and 6 each exhibited potent activity in comparison with the butylhydroxytoluene (BHT) positive control.

引用

页码：2731 / 2734

页数：4

共 19 条

[1] Novel DPPH radical scavengers, bisorbicillinol and demethyltrichodimerol, from a fungus [J].

Abe, N ;

Murata, T ;

Hirota, A .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (04) :661-666

[2] Bisorbibetanone, a novel oxidized sorbicillin dimer, with 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity from a fungus [J].

Abe, N ;

Murata, T ;

Yamamoto, K ;

Hirota, A .

TETRAHEDRON LETTERS, 1999, 40 (28) :5203-5206

[3] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[4] Marine natural products [J].

Blunt, John W. ;

Copp, Brent R. ;

Hu, Wan-Ping ;

Munro, Murray H. G. ;

Northcote, Peter T. ;

Prinsep, Michele R. .

NATURAL PRODUCT REPORTS, 2009, 26 (02) :170-244

[5] Marine-derived fungi: a chemically and biologically diverse group of microorganisms [J].

Bugni, TS ;

Ireland, CM .

NATURAL PRODUCT REPORTS, 2004, 21 (01) :143-163

[6] DPPH radical-scavenging compounds from dou-chi, a soybean fermented food [J].

Chen, YC ;

Sugiyama, Y ;

Abe, N ;

Kuruto-Niwa, R ;

Nozawa, R ;

Hirota, A .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2005, 69 (05) :999-1006

[7] Antioxidant properties of hydroxy-flavones [J].

Cotelle, N ;

Bernier, JL ;

Catteau, JP ;

Pommery, J ;

Wallet, JC ;

Gaydou, EM .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (01) :35-43

[8] CHEMICAL STUDIES OF MARINE-BACTERIA - DEVELOPING A NEW RESOURCE [J].

FENICAL, W .

CHEMICAL REVIEWS, 1993, 93 (05) :1673-1683

[9] Developing a new resource for drug discovery: marine actinomycete bacteria [J].

Fenical, William ;

Jensen, Paul R. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (12) :666-673

[10] THIN-LAYER CHROMATOGRAPHIC DETERMINATION OF ANTIOXIDANTS BY STABLE FREE RADICAL ALPHA ALPHA'-DIPHENYL-BETA-PICRYLHYDRAZYL [J].

GLAVIND, J ;

HOLMER, G .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1967, 44 (09) :539-&

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