Deafness induced up-regulation of GluR2/3 and NRI in the spiral ganglion cells of the rat cochlea

被引：4

作者：

Hasegawa, T ^{[1
]}

Doi, K ^{[1
]}

Fuse, Y ^{[1
]}

Fujii, K ^{[1
]}

Uno, Y ^{[1
]}

Nishimura, H ^{[1
]}

Kubo, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Otolaryngol & Sensory Organ Surg, Suita, Osaka 5650871, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 11期

关键词：

aminoglycoside; AMPA receptors; cochlea; NMDA receptors; spiral ganglion cells; up-regulation;

D O I：

10.1097/00001756-200008030-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expressions of AMPA (GluR2, GluR3, and GlUR4) and NMDA (NR1 and NR2) glutamate receptors in the spiral ganglion cells of the cochlea were analyzed both at protein and mRNA levels in control and deaf rats between week 0 (P14) and week 8 (P70) after deafness induced by a daily injection of kanamycin at P0-P14. In the deaf rats, significant up-regulations of GluR2, GluR3, and NRI in the surviving spiral ganglion cells were observed, while expressions of GlUR4 and NR2 were fairly constant. In contrast, in the control rats, the expressions of all these glutamate receptor subtypes were stable. These results suggest that drastic alterations in the diversity of GluR2/GluR3/NRI receptor complexes in the surviving spiral ganglion cells, which result in alterations in Ca2+ permeability, may contribute to the deafness-related alterations in the structure and function of the cochlea. NeuroReport 11:2515-2519 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：2515 / 2519

页数：5

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