Promomycin, a polyether promoting antibiotic production in Streptomyces spp.

被引：42

作者：

Amano, Sho-ichi ^{[1
]}

Morota, Tatsuya ^{[1
]}

Kano, Yu-ki ^{[1
]}

Narita, Hiroyuki ^{[1
]}

Hashidzume, Tohko ^{[1
]}

Yamamoto, Setsuya ^{[1
]}

Mizutani, Kotaro ^{[1
]}

Sakuda, Shohei ^{[2
]}

Furihata, Kazuo ^{[2
]}

Takano-Shiratori, Hatsumi ^{[1
]}

Takano, Hideaki ^{[1
]}

Beppu, Teruhiko ^{[1
]}

Ueda, Kenji ^{[1
]}

机构：

[1] Nihon Univ, Coll Bioresource Sci, Life Sci Res Ctr, Fujisawa, Kameino, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2010年 / 63卷 / 08期

关键词：

antibiotic production; ionophore; polyether; promomycin; Streptomyces; IONOPHOROUS ANTIBIOTICS; LONOMYCIN-A; MUTALOMYCIN; GROWTH;

D O I：

10.1038/ja.2010.68

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Widespread interspecific stimulation of antibiotic production occurs in strains of Streptomyces owing to the activity of diffusible substances, as previously determined in our investigations of the cross-feeding effect. In this study, we newly isolated a substance produced by a Streptomyces strain closely related to Streptomyces scabrisporus, based on the observation that this substance induced the production of an unknown antibiotic in another strain related to Streptomyces griseorubiginosus. This substance, named promomycin, is a polyether structurally related to lonomycin. Promomycin itself had an antibiotic activity, but it stimulated antibiotic production in multiple Streptomyces strains at sub-inhibitory concentrations. Evidence implies that this stimulation effect is widespread within this group of bacteria. The Journal of Antibiotics (2010) 63, 486-491, doi.10.1038/ja 2010 68. published online 23 June 2010

引用

页码：486 / 491

页数：6

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