Wnt Signaling and Biological Therapy in Rheumatoid Arthritis and Spondyloarthritis

被引：114
作者：
Cici, Daniela [1 ]
Corrado, Addolorata [1 ]
Rotondo, Cinzia [1 ]
Cantatore, Francesco P. [1 ]
机构：
[1] Univ Foggia, Dept Med & Surg Sci, Rheumatol Clin, I-71121 Foggia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期
关键词：
Wnt signaling; Dkk-1; biologics; rheumatoid arthritis; ankylosing spondylitis; axial spondyloarthritis; bone homeostasis; BONE-FORMATION; TNF-ALPHA; BETA-CATENIN; IN-VITRO; DICKKOPF-1; INHIBITION; SCLEROSTIN; EXPRESSION; OSTEOPOROSIS; DKK1;
D O I：
10.3390/ijms20225552
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Wnt signaling pathway plays a key role in several biological processes, such as cellular proliferation and tissue regeneration, and its dysregulation is involved in the pathogenesis of many autoimmune diseases. Several evidences support its role especially in bone complications of rheumatic diseases. In Rheumatoid Arthritis (RA), the Wnt signaling is implicated in systemic and localized bone loss, while available data of its role in Spondyloarthritis (SpA) are conflicting. In the last few decades, the quality of life of rheumatic patients has been dramatically improved by biological therapy, targeting cytokines involved in the pathogenesis of these diseases like tumor necrosis factor (TNF)alpha, interleukin (IL)-1, IL-6, IL-17. In this review, we reviewed the role of Wnt signaling in RA and SpA, focusing on the effect of biological therapy on this pathway and its possible clinical implications.
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页数：15
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