Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies

被引：47

作者：

Taghizadehghalehjoughi, Ali ^{[1
]}

Hacimuftuoglu, Ahmet ^{[2
]}

Cetin, Meltem ^{[3
]}

Ugur, Afife Busra ^{[3
]}

Galateanu, Bianca ^{[4
]}

Mezhuev, Yaroslav ^{[5
]}

Okkay, Ufuk ^{[2
]}

Taspinar, Numan ^{[2
]}

Taspinar, Mehmet ^{[6
]}

Uyanik, Abdullah ^{[7
]}

Gundogdu, Betul ^{[8
]}

Mohammadzadeh, Maryam ^{[2
]}

Nalci, Kemal Alp ^{[2
]}

Stivaktakis, Polychronis ^{[9
,10
]}

Tsatsakis, Aristidis ^{[9
,10
]}

Jung, Tae Woo ^{[11
]}

Jeong, Ji Hoon ^{[12
]}

Abd El-Aty, A. M. ^{[2
,13
]}

机构：

[1] Ataturk Univ, Dept Pharmacol & Toxicol, Fac Vet Sci, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Dept Med Pharmacol, Fac Med, TR-25240 Erzurum, Turkey

[3] Ataturk Univ, Dept Pharmaceut Technol, Fac Pharm, TR-25240 Erzurum, Turkey

[4] Dept Biochem & Mol Biol, 91-95 Splaiul Independentei,Dist 5, Bucharest 050095, Romania

[5] D Mendeleev Univ Chem Technol Russia, Ctr Biomat, Miusskaya Sq 9, Moscow 125047, Russia

[6] Yuzuncu Yil Univ, Sch Med, Dept Med Biol, Van, Turkey

[7] Ataturk Univ, Dept Nephrol, Fac Med, TR-25240 Erzurum, Turkey

[8] Ataturk Univ, Dept Pathol, Fac Med, TR-25240 Erzurum, Turkey

[9] Univ Crete, Toxicol Lab, Sch Med, Iraklion 71003, Greece

[10] Univ Crete Spin Off, Toxplus SA, Iraklion 71601, Greece

[11] Seoul Natl Univ, Res Adm Team, Bundang Hosp, Gyeonggi, South Korea

[12] Chung Ang Univ, Dept Pharmacol, Coll Med, Seoul, South Korea

[13] Cairo Univ, Dept Pharmacol, Fac Vet Med, Giza 12211, Egypt

来源：

NANOMEDICINE | 2018年 / 13卷 / 13期

关键词：

brain tumor; Cavalieri's principle; irinotecan; metformin; nanoparticles; PLGA; IRINOTECAN CPT-11; METFORMIN; CANCER; GROWTH; CELL; THERAPY; GLIOMA; ZINGIBERENE; MULTIFORME; CARCINOMA;

D O I：

10.2217/nnm-2017-0386

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. Methods: The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume). Results: 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Conclusion: Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme.

引用

页码：1595 / 1606

页数：12

共 50 条

[21] Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model
Gracia, Eulalio
Mancini, Andrea
Colapietro, Alessandro
Mateo, Cristina
Gracia, Ignacio
Festuccia, Claudio
Carmona, Manuel
NUTRIENTS, 2019, 11 (10)
[22] In Vitro and In Vivo Evaluation of Lidocaine Hydrochloride-loaded Injectable Poly(Lactic-co-glycolic Acid) Implants
Li, Yongqiang
Shi, Xiaowei
CURRENT DRUG DELIVERY, 2018, 15 (10) : 1411 - 1416
[23] Propolis-Loaded Poly(lactic-co-glycolic Acid) Nanofibers: An In Vitro Study
Geyik, Fulya
Kaya, Secil
Yilmaz, Duygu Elif
Demirci, Hasan
Akmayan, Ilkgul
Ozbek, Tulin
Acar, Serap
ACS OMEGA, 2024, 9 (12): : 14054 - 14062
[24] Levofloxacin loaded chitosan and poly-lactic-co-glycolic acid nano-particles against resistant bacteria: Synthesis, characterization and antibacterial activity
Hayee, Rabia
Iqtedar, Mehwish
Albekairi, Norah A.
Alshammari, Abdulrahman
Makhdoom, Mauhammad Atif
Islam, Muhammad
Ahmed, Nadeem
Rasool, Muhammad Fawad
Li, Chen
Saeed, Hamid
JOURNAL OF INFECTION AND PUBLIC HEALTH, 2024, 17 (05) : 906 - 917
[25] Studies on the oridonin-loaded poly(D,L-lactic acid) nanoparticles in vitro and in vivo
Xing, Jie
Zhang, Dianrui
Tan, Tianwei
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2007, 40 (02) : 153 - 158
[26] High glycolic poly (DL lactic co glycolic acid) nanoparticles for controlled release of meropenem
Nandakumar, Venkatesan
Geetha, Venkatachalam
Chittaranjan, Samuel
Doble, Mukesh
BIOMEDICINE & PHARMACOTHERAPY, 2013, 67 (05) : 431 - 436
[27] Fabrication of hesperidin nanoparticles loaded by poly lactic co-Glycolic acid for improved therapeutic efficiency and cytotoxicity
Ali, Saja H.
Sulaiman, Ghassan M.
Al-Halbosiy, Mohammad M. F.
Jabir, Majid S.
Hameed, Anaheed H.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2019, 47 (01) : 378 - 394
[28] Characteristics and anticancer properties of Sunitinib malate-loaded poly-lactic-co-glycolic acid nanoparticles against human colon cancer HT-29 cells lines
Alshetaili, Abdullah S.
Anwer, Md Khalid
Alshahrani, Saad M.
Alalaiwe, Ahmed
Alsulays, Bader B.
Ansari, Mohammad Javed
Imam, Faisal
Alshehri, Sultan
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (07) : 1263 - 1269
[29] Increased Osteoblalst Functions on (Poly-lactic-co-glycolic acid) with Highly Dispersed Nanophase Titania
Liu, Huinan
Slamovich, Elliott B.
Webster, Thomas J.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2005, 1 (01) : 83 - 89
[30] Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles
Elmowafy E.M.
Tiboni M.
Soliman M.E.
Journal of Pharmaceutical Investigation, 2019, 49 (4) : 347 - 380

← 1 2 3 4 5 →