Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies

被引：47

作者：

Taghizadehghalehjoughi, Ali ^{[1
]}

Hacimuftuoglu, Ahmet ^{[2
]}

Cetin, Meltem ^{[3
]}

Ugur, Afife Busra ^{[3
]}

Galateanu, Bianca ^{[4
]}

Mezhuev, Yaroslav ^{[5
]}

Okkay, Ufuk ^{[2
]}

Taspinar, Numan ^{[2
]}

Taspinar, Mehmet ^{[6
]}

Uyanik, Abdullah ^{[7
]}

Gundogdu, Betul ^{[8
]}

Mohammadzadeh, Maryam ^{[2
]}

Nalci, Kemal Alp ^{[2
]}

Stivaktakis, Polychronis ^{[9
,10
]}

Tsatsakis, Aristidis ^{[9
,10
]}

Jung, Tae Woo ^{[11
]}

Jeong, Ji Hoon ^{[12
]}

Abd El-Aty, A. M. ^{[2
,13
]}

机构：

[1] Ataturk Univ, Dept Pharmacol & Toxicol, Fac Vet Sci, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Dept Med Pharmacol, Fac Med, TR-25240 Erzurum, Turkey

[3] Ataturk Univ, Dept Pharmaceut Technol, Fac Pharm, TR-25240 Erzurum, Turkey

[4] Dept Biochem & Mol Biol, 91-95 Splaiul Independentei,Dist 5, Bucharest 050095, Romania

[5] D Mendeleev Univ Chem Technol Russia, Ctr Biomat, Miusskaya Sq 9, Moscow 125047, Russia

[6] Yuzuncu Yil Univ, Sch Med, Dept Med Biol, Van, Turkey

[7] Ataturk Univ, Dept Nephrol, Fac Med, TR-25240 Erzurum, Turkey

[8] Ataturk Univ, Dept Pathol, Fac Med, TR-25240 Erzurum, Turkey

[9] Univ Crete, Toxicol Lab, Sch Med, Iraklion 71003, Greece

[10] Univ Crete Spin Off, Toxplus SA, Iraklion 71601, Greece

[11] Seoul Natl Univ, Res Adm Team, Bundang Hosp, Gyeonggi, South Korea

[12] Chung Ang Univ, Dept Pharmacol, Coll Med, Seoul, South Korea

[13] Cairo Univ, Dept Pharmacol, Fac Vet Med, Giza 12211, Egypt

来源：

NANOMEDICINE | 2018年 / 13卷 / 13期

关键词：

brain tumor; Cavalieri's principle; irinotecan; metformin; nanoparticles; PLGA; IRINOTECAN CPT-11; METFORMIN; CANCER; GROWTH; CELL; THERAPY; GLIOMA; ZINGIBERENE; MULTIFORME; CARCINOMA;

D O I：

10.2217/nnm-2017-0386

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. Methods: The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume). Results: 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Conclusion: Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme.

引用

页码：1595 / 1606

页数：12

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