Labdane Diterpenes from the Aerial Parts of Curcuma comosa Enhance Fetal Hemoglobin Production in an Erythroid Cell Line

被引：36

作者：

Chokchaisiri, Ratchanaporn ^{[1
,2
]}

Chaneiam, Nattawara ^{[3
,4
]}

Svasti, Saovaros ^{[3
,5
]}

Fucharoen, Suthat ^{[3
,5
]}

Vadolas, Jim ^{[6
]}

Suksamran, Apichart ^{[1
,2
]}

机构：

[1] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[2] Ramkhamhang Univ, Fac Sci, Ctr Innovat Chem, Bangkok 10240, Thailand

[3] Mahidol Univ, Thalassemia Res Ctr, Inst Mol Biosci, Phutthamonthon 73170, Nakhon Pathom, Thailand

[4] Mahidol Univ, Inst Nutr, Phutthamonthon 73170, Nakhon Pathom, Thailand

[5] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand

[6] Royal Childrens Hosp, Murdoch Childrens Res Inst, CAGT Res Grp, Parkville, Vic 3052, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期

关键词：

BETA-HEMOGLOBINOPATHIES; HEDYCHIUM-CORONARIUM; THALASSEMIA; INDUCTION; RHIZOMES; DIARYLHEPTANOIDS; DIFFERENTIATION; HYDROXYUREA; THERAPY; SEEDS;

D O I：

10.1021/np900568k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new labdane diterpenes, curcucomosin A-C (1-3), four known labdane diterpenes, 4-7, and a known diarylheptanoid, 8, were isolated from the aerial parts of Curcuma comosa. The structures of the new diterpenes were elucidated by spectroscopic data analysis. The fetal hemoglobin (Hb F) induction potency of the isolated compounds was examined using a K562 reporter cell line harboring the enhanced green fluorescene protein (EGFP) gene under the control of a (G)gamma-globin promoter. Compound 6, D, exhibited the highest Hb F induction effect of 1.6-fold at 20 mu M.

引用

页码：724 / 728

页数：5

共 26 条

[1] Six new diarylheptanoids from the seeds of Alpinia blepharocalyx [J].