Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways

被引：21

作者：

Paulino, Niraldo ^{[1
,2
]}

Paulino, Amarilis Scremin ^{[3
]}

Diniz, Susana N. ^{[1
,2
]}

de Mendonca, Sergio ^{[1
,2
]}

Goncalves, Ivair D. ^{[1
,2
]}

Flores, Fernanda Faiao ^{[4
]}

Santos, Reginaldo Pereira ^{[1
,2
]}

Rodrigues, Carina ^{[1
,2
]}

Pardi, Paulo Celso ^{[1
,2
]}

Quincoces Suarez, Jose Agustin ^{[1
,2
]}

机构：

[1] Univ Anhanguera Sao Paulo UNIAN SP, Programa Posgrad Farm, Programa Mestrado Profiss Farm, Rua Maria Candida,1813 Vila Guilherme, BR-02071013 Sao Paulo, SP, Brazil

[2] Programa Mestrado & Doutorado Biotecnol & Inovaca, Rua Maria Candida,1813 Vila Guilherme, BR-02071013 Sao Paulo, SP, Brazil

[3] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, Campus Univ Trindade, BR-88040400 Florianopolis, SC, Brazil

[4] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Cidade Univ, BR-05508900 Sao Paulo, SP, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

DM1; Curcumin analog; Peritonitis; Edema; Anti-inflammatory; iNOS; COX-2; Autophagy; PROSTAGLANDIN-E SYNTHASE; NF-KAPPA-B; SENSORY NEUROPEPTIDES; INFLAMMATORY PAIN; SUBSTANCE-P; CARRAGEENAN; RATS; CANCER; CELLS; IDENTIFICATION;

D O I：

10.1016/j.bmc.2016.03.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1927 / 1935

页数：9

共 77 条

[1]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[2]

[Anonymous], 2013, [No title captured], Patent No. 1572614

[3]

[Anonymous], [No title captured], Patent No. 5317290

[4]

[Anonymous], 2008, [No title captured], Patent No. 7432401