Small Oligomers of Aβ42 Protein in the Bulk Solution with AlphaFold2

被引：21

作者：

Santuz, Hubert ^{[1
]}

Nguyen, Phuong H. ^{[1
]}

Sterpone, Fabio ^{[1
]}

Derreumaux, Philippe ^{[1
,2
]}

机构：

[1] Univ Paris, Fdn Edmond Rothschild, Inst Biol Phys Chim, Lab Biochim Theor,CNRS,UPR 9080, F-75005 Paris, France

[2] Inst Univ France IUF, F-75005 Paris, France

来源：

ACS CHEMICAL NEUROSCIENCE | 2022年 / 13卷 / 06期

关键词：

Amyloid-beta; Alzheimer's disease; simulations; AlphaFold2; monomers and small oligomers;

D O I：

10.1021/acschemneuro.2c00122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aggregation of amyloid-fi (A beta 42) protein is one hallmark of Alzheimer's disease, and the conformations of the smallest A beta 42 oligomers are largely unknown. Here, we explore the application of the deep learning AlphaFold2 method to the structure determination of A beta 42 monomers up to hexamers. The results shed light on the early A beta 42 aggregation steps in the bulk solution.

引用

页码：711 / 713

页数：3

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