A Novel and Regiospecific Synthesis of 1-Aryl-1H-benzotriazoles via Copper(I)-Catalyzed Intramolecular Cyclization Reaction

被引：25

作者：

Liu, Qi-Lun ^{[1
]}

Wen, Di-Di ^{[1
]}

Hang, Chen-Chen ^{[1
]}

Li, Qiu-Lian ^{[1
]}

Zhu, Yong-Ming ^{[1
]}

机构：

[1] Soochow Univ, Sch Pharm, Suzhou 215123, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2010年 / 93卷 / 07期

关键词：

BENZYNE-CLICK CHEMISTRY; AMINATION REACTION; DERIVATIVES; BENZOTRIAZOLES; 1H-BENZOTRIAZOLES; ARYLATION; ACCESS; AZIDES;

D O I：

10.1002/hlca.200900384

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1-Aryl-1H-benzotriazole derivatives were synthesized via intramolecular cyclization of easily obtained triazenes, using CuI as the catalyst. DMSO as the solvent, t-BuONa as the base, and 1,10-phenanthroline as the ligand, in up to 97% yield. The synthesis is regiospecific and functional group-tolerant.

引用

页码：1350 / 1354

页数：5

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