Apoptotic microparticles mediate the association between bisphenol A and subclinical atherosclerosis in a young population: A population-based study

被引：6

作者：

Chu, Pei-Lun ^{[1
,2
]}

Lin, Chien-Yu ^{[1
,3
,4
]}

Sung, Fung-Chang ^{[5
,6
]}

Su, Ta-Chen ^{[7
,8
,9
]}

机构：

[1] Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei 242, Taiwan

[2] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Internal Med, New Taipei 242, Taiwan

[3] Chu Kong Hosp, Dept Internal Med, New Taipei 237, Taiwan

[4] Yuanpei Univ Med Technol, Dept Environm Engn & Hlth, Hsinchu 300, Taiwan

[5] China Med Univ, Dept Hlth Serv Adm, Coll Publ Hlth, Taichung 404, Taiwan

[6] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung 413, Taiwan

[7] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, 7 Chung Shan South Rd, Taipei 100, Taiwan

[8] Natl Taiwan Univ Hosp, Dept Internal Med & Cardiovasc Ctr, Taipei 100, Taiwan

[9] Natl Taiwan Univ, Inst Environm & Occupat Hlth Sci, Coll Publ Hlth, Taipei 100, Taiwan

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2021年 / 224卷

关键词：

Bisphenol A (BPA); Carotid artery intima-media thickness (CIMT); Microparticle; Atherosclerosis; PLATELET-DERIVED MICROPARTICLES; ENDOTHELIAL MICROPARTICLES; IN-VIVO; THICKNESS; RISK; ADOLESCENTS; ACTIVATION; EXPOSURE; DYSFUNCTION; BIOMARKERS;

D O I：

10.1016/j.ecoenv.2021.112663

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bisphenol A (BPA) exposure is associated with atherosclerotic cardiovascular diseases. The interactions between BPA, extracellular microparticles (MPs), and atherosclerosis are unknown. A total of 103,756 young students participated in the mass urine-screening program in Taiwan between 1992 and 2000 were analyzed. After exclusion, 886 subjects were recruited to test the relationships between serum level of BPA, endothelial and platelet MPs as well as subclinical atherosclerosis represented by carotid artery intima-media thickness (CIMT). We found that an increment of one unit of log-BPA could lead to significant association between thicker CIMT and concentrations of endothelial microparticles and platelet microparticles in the cohort (odds ratio (OR) 1.23, P 0.001). CD31 + /CD42a- ( 50%, OR 1.262, P = 0.017 and 50%, OR 1.356, P = 0.029; CD31 +/CD42a- 50% and CD31 +/CD42a+ > 50%, OR 1.204, P = 0.014). Our study identified a higher risk of thicker CIMT associated with altered MPs in the presence of elevated BPA levels. BPA exposure is associated with endothelial dysfunction and subclinical atherosclerosis in a young population.

引用

页数：7

共 48 条

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