Synthesis of naturally occurring naphthoquinone epoxides and application in the synthesis of β-lapachone

被引：13

作者：

Claessens, Sven ^{[1
]}

Habonimana, Pascal ^{[1
]}

De Kimpe, Norbert ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Fac Biosci Engn, B-9000 Ghent, Belgium

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 16期

关键词：

PROSTATE-CANCER CELLS; MOLLUSCICIDAL ACTIVITY; TRYPANOCIDAL ACTIVITY; INDUCED APOPTOSIS; EPOXIDATION; INDUCTION; OXIDATION; QUINONES; KETONES; DRUGS;

D O I：

10.1039/c004580b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optimized epoxidation conditions of mono- and dialkylated naphthoquinones are presented. Based on the epoxidation protocol making use of H2O2/Na2CO3, naphthoquinone epoxides are obtained in high yields. The optimized epoxidation conditions are applied in a short and high yielding synthesis of the pharmaceutically important beta-lapachone.

引用

页码：3790 / 3795

页数：6

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