Sol-gel processing of drug delivery materials and release kinetics

被引：46

作者：

De Gaetano, F ^{[1
]}

Ambrosio, L ^{[1
]}

Raucci, MG ^{[1
]}

Marotta, A ^{[1
]}

Catauro, M ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Mat & Prod Engn, I-80125 Naples, Italy

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2005年 / 16卷 / 03期

关键词：

D O I：

10.1007/s10856-005-6688-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Silica, calcium ( 5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems. (C) 2005 Springer Science + Business Media, Inc.

引用

页码：261 / 265

页数：5

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