ASSOCIATION OF THE DELETION ALLELE OF THE INSERTION/DELETION POLYMORPHISM OF αllbβ3 INTEGRIN GENE AND METABOLIC SYNDROME IN YOUNG NORTHERNERS

The rationale for the present study is explained by a high spread of metabolic syndrome among the young population, living in an area equivalent to the Far North. The study is aimed at the investigation of the association between a deletion allele of the polymorphism of deletion/insertion in the alit:1133 integrin gene and metabolic syndrome in young residents Khanty-Mansiysk Autonomous Okrug - Ugra (Russia). The 758 young people aged 18-44 (mean age 36.62 +/- 5.12 years old) with metabolic syndrome and 77 healthy young people without metabolic disorders were examined. The carriership of the allele I associated with the cardiovascular risk was revealed in 63% of the examined patients that had an increased risk of the development of metabolic disorders (OR 1.409, 95% CI 0.858-2.311, p=0.253). There was no significant difference between the native and non-native populations in the rate of occurrence of allele I (62.2% and 64.7%). Genotype II had significant association with arterial hypertension (OR 1.377, 95 % CI 0.912-2.080, p=0.073), obesity (OR 1.353, 95% CI 0.825-2.219, p=0.071), hypercholesterinemia (OR 1.386, 95% CI 0.977-1.966, p=0.115), hypertriglyceridemia (OR 1.232, 95% CI 0.889-1.706, p=0.097). It was established that the non-native population had a higher risk of the development of abdominal obesity, arterial hypertension, and hypercholesterinemia, unlike the native population that had a significantly higher risk of the development of triglyceridemia. The materials of the article can be useful for the evaluation of genetic predisposition to myocardial infarction, stroke, and thromboembolism, which will allow for timely indication of preventive measures.