Triterpene glycosides with in vitro anti-inflammatory activity from Cyclamen repandum tubers

被引：24

作者：

Dall'Acqua, Stefano ^{[1
]}

Castagliuolo, Ignazio ^{[2
]}

Brun, Paola ^{[2
]}

Ditadi, Federica ^{[2
]}

Palu, Giorgio ^{[2
]}

Innocenti, Gabbriella ^{[1
]}

机构：

[1] Univ Padua, Dept Pharmaceut Sci, I-35100 Padua, Italy

[2] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35100 Padua, Italy

来源：

CARBOHYDRATE RESEARCH | 2010年 / 345卷 / 05期

关键词：

Triterpene glycosides; Anti-inflammatory activity; Cyclamen repandum; SAPONIN; COUM;

D O I：

10.1016/j.carres.2009.12.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new triterpene glycoside, repandoside (1) was isolated together with six known saponins (2-7) from the methanol extract of Cyclamen repandum tubers. The isolated saponins were characterized by high resolution mass spectrometry and both 1D and 2D NMR experiments. The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages. We found that compounds 1 (repandoside), 2 (deglucocyclamin) and 4 (anagalloside B) at 100 mu M inhibited the LPS-induced IL-8 and TNF-alpha expressions. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：709 / 714

页数：6

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