Increased VEGFR2 and MMP9 protein levels are associated with epithelial dysplasia grading

被引：20
作者：
de Carvalho Fraga, Carlos Alberto [1 ]
Farias, Lucyana Conceicao [1 ]
Macedo de Oliveira, Marcos Vinicius [1 ]
Batista Domingos, Patricia Luciana [1 ]
Pereira, Camila Santos [1 ]
Silva, Thiago Fonseca [1 ]
Roy, Ashbeel [2 ]
Gomez, Ricardo Santiago [3 ]
Batista de Paula, Alfredo Mauricio [1 ]
Sena Guimaraes, Andre Luiz [1 ]
机构：
[1] Univ Estadual Montes Claros, Dept Dent, BR-39401001 Montes Claros, MG, Brazil
[2] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5K8, Canada
[3] Univ Fed Minas Gerais, Sch Dent, Dept Clin Surg & Oral Pathol, Belo Horizonte, MG, Brazil
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2014年 / 210卷 / 12期
关键词：
Angiogenesis; Leukoplakia; Oral cancer; Oral potentially malignant disorders; Transformation; ENDOTHELIAL GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMAS; MATRIX METALLOPROTEINASES; MICROVESSEL DENSITY; ORAL LESIONS; EXPRESSION; RECEPTORS; ANGIOGENESIS; CANCER; FLK-1;
D O I：
10.1016/j.prp.2014.06.020
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The present study aimed to compare levels of VEGFR2 and MMP-9 among control, epithelial dysplasia (ED) and oral squamous cell carcinoma (OSCC) groups. We analyzed 48 patients with oral leukoplakia (OL), 20 patients with OSCC and 21 patients without OL and OSCC. Immunohistochemistry of VEGFR2 and MMP9 were performed and compared among groups. Analysis of tissue immunolocalization of VEGFR2 and MMP-9 assumed non-parametrical distribution and comparison between groups was performed using the Mann-Whitney and Kruskal-Wallis statistical tests. VEGFR2 and MMP9 immunoexpression appeared to correlate with the degree of dysplasia and was observed to increase in lesions with more severe dysplasia as compared to those with lower degrees of dysplasia. Immunoreactivity of MMP-9 was lower in the OL samples compared to the OSCC samples (p = 0.004). We observed no difference in VEGFR2 protein levels between OL and OSCC samples. A positive correlation was found between VEGFR2 and MMP-9 in OL samples (r = +0.452, p = 0.001), however, no correlation was found in OSCC samples (r = -0.042, p = 0.861). In conclusion, the results of the current study suggest that expression of MMP9 and VEGFR2 is associated with ED grading and MMP9 levels are increased in OSCC. (C) 2014 Elsevier GmbH. All rights reserved.
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收藏
页码：959 / 964
页数：6
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