Vasopressin mechanism-mediated pressor responses caused by central angiotensin II in the ovine fetus

被引:16
作者
Shi, LJ
Guerra, C
Yao, JM
Xu, Z
机构
[1] Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Torrance, CA 90502 USA
[2] Res & Educ Inst, Torrance, CA 90502 USA
[3] Soochow Univ, Sch Med, Suzhou 215007, Peoples R China
关键词
D O I
10.1203/01.PDR.0000141519.85908.68
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
AVP not only influences renal water excretion but also has profound cardiovascular effects in adults. Our recent studies have demonstrated that central angiotensin induced fetal pressor responses accompanied with AVP release. However, little is known of hormonal mechanisms in angiotensin-mediated fetal blood pressure (BP) changes. The present study determined AVP mechanisms in central angiotensin-mediated fetal pressor responses. The V1-receptor antagonist or V2-receptor antagonist was infused intravenously into the ovine fetus at 90% gestation. Angiotensin II (Ang II; 1.5 mug/kg) was then injected intracere-broventricularly into the chronically instrumented fetus. Ang II produced a significant increase in fetal systolic, diastolic, and mean arterial pressure adjusted to amniotic pressure (A-MAP). The enhanced fetal A-MAP was associated with intense c-fos expression in the central putative cardiovascular area: the para-ventricular nuclei (PVN). Double labeling demonstrated that a number of the AVP-containing neurons in the PVN were expressing c-fos in response to central Ang II. Consistent with the activation of AVP neurons in the PVN, fetal plasma AVP was markedly enhanced. Fetal i.v. V1-receptor antagonist or V2-receptor antagonist had no effect on either fetal or maternal baseline BP. However, intracerebroventricular Ang II-increased BP was partially inhibited, although not completely abolished, by the V1-receptor blockade. In contrast, fetal i.v. infusion of V2-receptor antagonist had no effect on the pressor responses induced by central Ang II. The results suggest that the central Ang II-mediated pressor responses at the last third of gestation is mediated partially by the AVP mechanism via V1 not V2 receptors.
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页码:756 / 762
页数:7
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