Biophysical Mechanisms Mediating Fibrin Fiber Lysis

被引:53
作者
Hudson, Nathan E. [1 ]
机构
[1] East Carolina Univ, Dept Phys, N304 Howell Sci Complex, Greenville, NC 27858 USA
关键词
TISSUE-PLASMINOGEN-ACTIVATOR; CATALYZED CROSS-LINKING; SINGLE-CHAIN UROKINASE; ALPHA-C REGION; COAGULATION FACTOR-XIII; RAY CRYSTAL-STRUCTURE; PLATELET FACTOR-XIII; ALPHA-2-PLASMIN INHIBITOR; MOLECULAR-MECHANISMS; CLOT RETRACTION;
D O I
10.1155/2017/2748340
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The formation and dissolution of blood clots is both a biochemical and a biomechanical process. While much of the chemistry has been worked out for both processes, the influence of biophysical properties is less well understood. This review considers the impact of several structural and mechanical parameters on lytic rates of fibrin fibers. The influences of fiber and network architecture, fiber strain, FXIIIa cross-linking, and particle transport phenomena will be assessed. The importance of the mechanical aspects of fibrinolysis is emphasized, and future research avenues are discussed.
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页数:17
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