Recent Progress of Microfluidics in Translational Applications

被引：30

作者：

Liu, Zongbin ^{[1
,2
]}

Han, Xin ^{[1
,2
]}

Qin, Lidong ^{[1
,2
,3
]}

机构：

[1] Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

[2] Cornell Univ, Dept Cell & Dev Biol, Weill Med Coll, New York, NY 10065 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2016年 / 5卷 / 08期

关键词：

cellular analysis; chip-based material delivery; microfluidics; molecular analysis; organ-on-a-chip; CIRCULATING TUMOR-CELLS; BAR-CHART CHIP; ON-A-CHIP; SINGLE CELLS; LABEL-FREE; CANCER-PATIENTS; BREAST-CANCER; STEM-CELLS; RNA-SEQ; CAPTURE;

D O I：

10.1002/adhm.201600009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Microfluidics, featuring microfabricated structures, is a technology for manipulating fluids at the micrometer scale. The small dimension and flexibility of microfluidic systems are ideal for mimicking molecular and cellular microenvironment, and show great potential in translational research and development. Here, the recent progress of microfluidics in biological and biomedical applications, including molecular analysis, cellular analysis, and chip-based material delivery and biomimetic design is presented. The potential future developments in the translational microfluidics field are also discussed.

引用

页码：871 / 888

页数：18

共 130 条

[1] Microfluidic heart on a chip for higher throughput pharmacological studies [J].

Agarwal, Ashutosh ;

Goss, Josue Adrian ;

Cho, Alexander ;

McCain, Megan Laura ;

Parker, Kevin Kit .

LAB ON A CHIP, 2013, 13 (18) :3599-3608

[2] A physical sciences network characterization of non-tumorigenic and metastatic cells [J].

Agus, David B. ;

Alexander, Jenolyn F. ;

Arap, Wadih ;

Ashili, Shashanka ;

Aslan, Joseph E. ;

Austin, Robert H. ;

Backman, Vadim ;

Bethel, Kelly J. ;

Bonneau, Richard ;

Chen, Wei-Chiang ;

Chen-Tanyolac, Chira ;

Choi, Nathan C. ;

Curley, Steven A. ;

Dallas, Matthew ;

Damania, Dhwanil ;

Davies, Paul C. W. ;

Decuzzi, Paolo ;

Dickinson, Laura ;

Estevez-Salmeron, Luis ;

Estrella, Veronica ;

Ferrari, Mauro ;

Fischbach, Claudia ;

Foo, Jasmine ;

Fraley, Stephanie I. ;

Frantz, Christian ;

Fuhrmann, Alexander ;

Gascard, Philippe ;

Gatenby, Robert A. ;

Geng, Yue ;

Gerecht, Sharon ;

Gillies, Robert J. ;

Godin, Biana ;

Grady, William M. ;

Greenfield, Alex ;

Hemphill, Courtney ;

Hempstead, Barbara L. ;

Hielscher, Abigail ;

Hillis, W. Daniel ;

Holland, Eric C. ;

Ibrahim-Hashim, Arig ;

Jacks, Tyler ;

Johnson, Roger H. ;

Joo, Ahyoung ;

Katz, Jonathan E. ;

Kelbauskas, Laimonas ;

Kesselman, Carl ;

King, Michael R. ;

Konstantopoulos, Konstantinos ;

Kraning-Rush, Casey M. ;

Kuhn, Peter .

SCIENTIFIC REPORTS, 2013, 3

[3] Cellular Heterogeneity and Molecular Evolution in Cancer [J].

Almendro, Vanessa ;

Marusyk, Andriy ;

Polyak, Kornelia .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8, 2013, 8 :277-302

[4]

An F, 2015, ANAL CHEM INSIGHTS, V10, P39, DOI [10.4137/ACI.S28905, 10.4137/ACICI.S28905]

[5] The human plasma proteome - History, character, and diagnostic prospects [J].

Anderson, NL ;

Anderson, NG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867

[6] A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone [J].

Bersini, Simone ;

Jeon, Jessie S. ;

Dubini, Gabriele ;

Arrigoni, Chiara ;

Chung, Seok ;

Charest, Joseph L. ;

Moretti, Matteo ;

Kamm, Roger D. .

BIOMATERIALS, 2014, 35 (08) :2454-2461

[7] Engineers are from PDMS-land, Biologists are from Polystyrenia [J].

Berthier, Erwin ;

Young, Edmond W. K. ;

Beebe, David .

LAB ON A CHIP, 2012, 12 (07) :1224-1237

[8] Microfluidic organs-on-chips [J].

Bhatia, Sangeeta N. ;

Ingber, Donald E. .

NATURE BIOTECHNOLOGY, 2014, 32 (08) :760-772

[9] Microfluidic platform for the quantitative analysis of leukocyte migration signatures [J].

Boneschansker, Leo ;

Yan, Jun ;

Wong, Elisabeth ;

Briscoe, David M. ;

Irimia, Daniel .

NATURE COMMUNICATIONS, 2014, 5

[10] Characterizing deformability and surface friction of cancer cells [J].

Byun, Sangwon ;

Son, Sungmin ;

Amodei, Dario ;

Cermak, Nathan ;

Shaw, Josephine ;

Kang, Joon Ho ;

Hecht, Vivian C. ;

Winslow, Monte M. ;

Jacks, Tyler ;

Mallick, Parag ;

Manalis, Scott R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (19) :7580-7585

← 1 2 3 4 5 6 7 8 9 10 →