SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia

被引：28

作者：

Mo, Yunan ^{[1
,2
]}

Deng, Songyun ^{[1
]}

Zhang, Lina ^{[1
,2
]}

Huang, Yan ^{[1
]}

Li, Wenchao ^{[1
]}

Peng, Qianyi ^{[1
]}

Liu, Zhiyong ^{[1
]}

Ai, Yuhang ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Crit Care Med, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 520卷 / 01期

基金：

中国国家自然科学基金;

关键词：

SS-31; Fis1; Lipopolysaccharide; Microglia; Oxidative stress; MITOCHONDRIAL DYSFUNCTION; DYNAMICS; FISSION; RESPONSES; ACTIVATION; APOPTOSIS; PROTECTS; DISEASE; MODELS; CANCER;

D O I：

10.1016/j.bbrc.2019.09.077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SS-31 is a kind of mitochondrion-targeted peptide. Recent studies indicated significant neuroprotective effects of SS-31. In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology. The morphological study showed that SS-31 preserved LPS-induced mitochondrial ultrastructure by reducing the fission protein 1 (Fis1) expression. Flow cytometry and Western blot verified that SS-31 defended the BV-2 cells against LPS-stimulated inflammation and oxidative stress via suppressing Fis1. To sum up, our study represents that SS-31 preserves BV-2 cells from LPS-stimulated inflammation and oxidative stress by down-regulating the Fis1 expression. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：171 / 178

页数：8

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