Clinical strains of Streptococcus agalactiae carry two different variants of pathogenicity island XII

被引:1
作者
Kuleshevich, Eugenia [1 ]
Ferretti, Joseph [2 ]
Sanches, Ilda Santos [3 ]
Balasubramanian, Natesan [3 ]
Spellerberg, Barbara [4 ]
Efstratiou, Androulla [5 ]
Kriz, Paula [6 ]
Grabovskaya, Kornelia [1 ]
Arjanova, Olga [7 ]
Savitcheva, Alevtina [7 ]
Shevchenko, Valentin [1 ]
Rysev, Anton [1 ]
Suvorov, Alexander [1 ,8 ]
机构
[1] Inst Expt Med, Pavlova St 12, St Petersburg 197376, Russia
[2] Univ Oklahoma, Hlth Sci Ctr, 1100 N Lindsay Ave, Oklahoma City, OK 73104 USA
[3] Univ Nova Lisboa, Fac Ciencias & Tecnol, Res Unit Appl Mol Biosci UCIBIO REQUIMTE, P-2829516 Caparica, Portugal
[4] Inst Med Microbiol & Hyg, Albert Einstein Allee 11, D-89081 Ulm, Germany
[5] Hlth Protect Agcy, 61 Colindale Ave, London NW9 5EQ, England
[6] WHO, Ctr Reference & Res Streptococci, Srobarova 48, Prague 10042 10, Czech Republic
[7] DO Ott Res Inst Obstet & Gynecol, Mendeleevskaya Line 3, St Petersburg 199034, Russia
[8] St Petersburg State Univ, Univ Skaya Emb 7-9, St Petersburg 199034, Russia
关键词
C5A PEPTIDASE GENES; GROUP-B; GROUP-A; MENINGITIS; EVOLUTION; ELEMENTS; IMPACT; GBS;
D O I
10.1007/s12223-017-0509-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Streptococcus agalactiae or Group B streptococci (GBS) are a common cause of serious diseases of newborns and adults. GBS pathogenicity largely depends on genes located on the accessory genome including several pathogenicity islands (PAI). The present paper is focused on the structure and molecular epidemiological analysis of one of the GBS pathogenicity islands-the pathogenicity island PAI XII (Glaser et al. Mol Microbiol 45(6):1499-1513, 2002). This PAI was found to be composed of three different mobile genetic elements: a composite transposon (PAI-C), a genomic islet (PAI-B), and a pathogenicity island associated with gene sspB1 (PAI-A). PAI-A in GBS has a homolog--PAI-A1 with similar, but a different genetic constellation. PCR-based analysis of GBS collections from different countries revealed that a strains lineage with PAI-A is less common than PAI-A1 and was determined to be present only among the strains obtained from Russia. Our results suggest that PAI-A and PAI-A1 have the same progenitor, which evolved independently and appeared in the GBS genome as separate genetic events. Results of this study reflect specific geographical distribution of the GBS strains with the mobile genetic element under study.
引用
收藏
页码:393 / 399
页数:7
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