Faster cyclic loess: normalizing RNA arrays via linear models

被引：157

作者：

Ballman, KV ^{[1
]}

Grill, DE ^{[1
]}

Oberg, AL ^{[1
]}

Therneau, TM ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Div Biostat, Coll Med, Rochester, MN 55905 USA

来源：

BIOINFORMATICS | 2004年 / 20卷 / 16期

关键词：

D O I：

10.1093/bioinformatics/bth327

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Our goal was to develop a normalization technique that yields results similar to cyclic loess normalization and with speed comparable to quantile normalization. Results: Fastlo yields normalized values similar to cyclic loess and quantile normalization and is fast; it is at least an order of magnitude faster than cyclic loess and approaches the speed of quantile normalization. Furthermore, fastlo is more versatile than both cyclic loess and quantile normalization because it is model-based.

引用

页码：2778 / 2786

页数：9

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