Prenatal noise and restraint stress interact to alter exploratory behavior and balance in juvenile rats, and mixed stress reverses these effects

被引:17
作者
Badache, Soumeya [1 ]
Bouslama, Slim [2 ]
Brahmia, Oualid [3 ]
Bairi, Abdel Madjid [4 ]
Tahraoui, Abdel Krim [4 ]
Ladjama, Ali [1 ]
机构
[1] Univ Badji Mokhtar Annaba, Fac Sci, Dept Biochem, Lab Biochem & Appl Microbiol, Annaba, Algeria
[2] Univ Badji Mokhtar Annaba, Fac Sci, Dept Biochem, Annaba, Algeria
[3] Univ Badji Mokhtar Annaba, Fac Med Sci, Dept Med, Annaba, Algeria
[4] Univ Badji Mokhtar Annaba, Fac Sci, Dept Biol, Lab Appl Neuroendocrinol, Annaba, Algeria
来源
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS | 2017年 / 20卷 / 03期
关键词
Anxiety; balance; beam walking; locomotion; noise; prenatal stress; ELEVATED PLUS-MAZE; MATERNAL STRESS; SPATIAL MEMORY; EXPOSURE; RECEPTOR; ANXIETY; MICE; CONSEQUENCES; HIPPOCAMPUS; EXPRESSION;
D O I
10.1080/10253890.2017.1307962
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We aimed to investigate in adolescent rats the individual and combined effects of prenatal noise and restraint stress on balance control, exploration, locomotion and anxiety behavior. Three groups of pregnant rats were exposed to daily repeated stress from day 11 to day 19 of pregnancy: 3min noise (Noise Stress, NS); 10min restraint (restraint stress, RS); or 3min noise followed by 10min restraint (mixed stress, MS). On postnatal days (PND) 44, 45 and 46, four groups of male rats (Control, NS, RS:, MS; 16 rats each), were tested as follows: (1) beam walking (BW), (2) open field (OF) and (3) elevated plus maze (EPM). Our results show that the NS group had significantly impaired balance control, locomotion and both horizontal and vertical exploration (p<.01 for all measures). The RS group showed only a decrease in vertical exploration (p<.05). In contrast, locomotion and balance were not affected in the MS group (OF: crossed squares: p=.34, missteps: p=.18). However, MS rats exhibited significantly higher anxiety levels (less time in EPM open arms: p<.05), and took more time to complete BW: p<.05). Hence, combined prenatal stressors exert non-additive effects on locomotion, exploration and balance control, but induce greater anxiety through additive effects. Terminal plasma ACTH concentration was increased by prenatal stress, especially noise, which group had the largest adrenal glands. Overall, contrary to expectation, combined prenatal stressors can interact to increase anxiety level, but diminish alteration of exploration, locomotion and impaired balance control, which were strongly induced by noise stress.Lay summary: Experience of stress in pregnancy can have negative effects on the offspring that are long-lasting. Here, we used laboratory rats to see whether repeated episodes of exposure to loud noise or preventing free movement, alone or together, during pregnancy had different effects on behaviors of the adolescent offspring. Using standard tests, we found the prenatal stresses caused the offspring to be anxious, and not to balance when moving around as well as normal offspring; the degree of impairment depended on the type of stress - loud noise exposure had the greatest effects, but if the stresses were combined the effects were not worse. The results point to the need to aim to avoid stress in pregnant women.
引用
收藏
页码:320 / 328
页数:9
相关论文
共 39 条
[1]  
Appart A, 2016, LE TROUBLE ADAPTATI
[2]   Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring [J].
Babri, Shirin ;
Doosti, Mohammad-Hossein ;
Salari, Ali-Akbar .
BRAIN BEHAVIOR AND IMMUNITY, 2014, 37 :164-176
[3]  
Barbazanges A, 1996, J NEUROSCI, V16, P3943
[4]   Auditory and non-auditory effects of noise on health [J].
Basner, Mathias ;
Babisch, Wolfgang ;
Davis, Adrian ;
Brink, Mark ;
Clark, Charlotte ;
Janssen, Sabine ;
Stansfeld, Stephen .
LANCET, 2014, 383 (9925) :1325-1332
[5]   Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression [J].
Benoit, Jamie D. ;
Rakic, Pasko ;
Frick, Karyn M. .
BEHAVIOURAL BRAIN RESEARCH, 2015, 281 :1-8
[6]   Effects of prenatal exposure to a mild chronic variable stress on body weight, preweaning mortality and rat behavior [J].
Cabrera, RJ ;
Rodríguez-Echandía, EL ;
Jatuff, ASG ;
Fóscolo, M .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1999, 32 (10) :1229-1237
[7]   DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 131/2 years: Project Ice Storm [J].
Cao-Lei, Lei ;
Dancause, Kelsey N. ;
Elgbeili, Guillaume ;
Massart, Renaud ;
Szyf, Moshe ;
Liu, Aihua ;
Laplante, David P. ;
King, Suzanne .
EPIGENETICS, 2015, 10 (08) :749-761
[8]   Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits [J].
Caspi, Avshalom ;
Hariri, Ahmad R. ;
Holmes, Andrew ;
Uher, Rudolf ;
Moffitt, Terrie E. .
AMERICAN JOURNAL OF PSYCHIATRY, 2010, 167 (05) :509-527
[9]   Functional Specializations of the Ventral Intraparietal Area for Multisensory Heading Discrimination [J].
Chen, Aihua ;
DeAngelis, Gregory C. ;
Angelaki, Dora E. .
JOURNAL OF NEUROSCIENCE, 2013, 33 (08) :3567-3581
[10]   The neural encoding of self-generated and externally applied movement: implications for the perception of self-motion and spatial memory [J].
Cullen, Kathleen E. .
FRONTIERS IN INTEGRATIVE NEUROSCIENCE, 2014, 7