Anionic cyclisations of an N-benzyl naphthamide:: a route to benzo[e]isoindolones

被引：65

作者：

Ahmed, A

Clayden, J

Rowley, M

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 03期

关键词：

D O I：

10.1039/a707683e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

On treatment with (BuLi)-Li-t and HMPA, N-tert-butyl-N-benzyl-1-naphthamide undergoes cyclisation to a tricyclic enolate which reacts diastereoselectively with electrophiles to give substituted 2,3,3a,9b-tetrahydro-1H-benzo[e]isoindol-1-ones, the first example of an anionic cyclisation onto an aromatic ring.

引用

页码：297 / 298

页数：2

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